@article{oai:hirosaki.repo.nii.ac.jp:00003762,
 author = {Hasui, Keisuke and Sakuraba, Hirotake and Ishiguro, Yoh and Hiraga, Hiroto and Fukuda, Shinsaku},
 issue = {2-4},
 journal = {弘前医学},
 month = {Feb},
 note = {Subclinical inflammation and radiographic progression have been described in rheumatoid arthritis patients in clinical remission state. The aim of this study was to compare the effect of biologics and nonbiologics treatment for reduction of subclinical inflammation estimated by magnetic resonance imaging （MRI）. Clinical remission was judged according to the Disease Activity Score （DAS） 28-ESR. Dominant hand and wrist was evaluated using a conventional 1.5 or 3T MRI scanner. Synovitis, erosions and bone marrow edema were scored according to the Simplified Rheumatoid Arthritis MR Imaging Score （SAMIS）. Twenty four patients who had reached to clinical remission with biologics（n=14） or nonbiologics（n=10） were included in the study. There were no significant differences in DAS28-ESR, Simplified Disease activity Index（SDAI）, and Matrix Metalloproteinase（MMP）-3 between the biologics group and the nonbiologics group at clinical remission. However, SAMIS and bone edema score in the biologics group were significantly lower than that in the nonbiologics group. Our results suggested that biologics treatment might be superior to nonbiologics treatment to suppress bone edema and to regulate subclinical inflammation., 弘前医学. 64(2-4), 2014, p.119-126},
 pages = {119--126},
 title = {Biologic Therapy Suppresses Subclinical Inflammation Identified by Magnetic Resonance Imaging in Rheumatoid Arthritis Patients in Clinical Remission State},
 volume = {64},
 year = {2014}
}