{"created":"2023-05-15T09:02:52.580054+00:00","id":3762,"links":{},"metadata":{"_buckets":{"deposit":"d20d4e92-5ce7-4e1b-9cd5-1f7615fa8399"},"_deposit":{"created_by":3,"id":"3762","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3762"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003762","sets":["557:561:653"]},"author_link":["11701","13575","11696","11691","11678","11181","11489","13580","11172","11686","11498","11509","13572","11191","11683"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"関節リウマチ患者に対する生物学的製剤による治療は臨床的寛解時におけるMRIで検出される潜在的関節炎を抑制する"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"カンセツ　リウマチ　カンジャ　ニ　タイスル　セイブツガクテキ　セイザイ　ニ　ヨル　チリョウ　ワ　リンショウテキ　カンカイジ　ニ　オケル　MRI　デ　ケンシュツ　サレル　センザイテキ　カンセツエン　オ　ヨクセイ　スル"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"126","bibliographicPageStart":"119","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Subclinical inflammation and radiographic progression have been described in rheumatoid arthritis patients in clinical remission state. The aim of this study was to compare the effect of biologics and nonbiologics treatment for reduction of subclinical inflammation estimated by magnetic resonance imaging （MRI）. Clinical remission was judged according to the Disease Activity Score （DAS） 28-ESR. Dominant hand and wrist was evaluated using a conventional 1.5 or 3T MRI scanner. Synovitis, erosions and bone marrow edema were scored according to the Simplified Rheumatoid Arthritis MR Imaging Score （SAMIS）. Twenty four patients who had reached to clinical remission with biologics（n=14） or nonbiologics（n=10） were included in the study. There were no significant differences in DAS28-ESR, Simplified Disease activity Index（SDAI）, and Matrix Metalloproteinase（MMP）-3 between the biologics group and the nonbiologics group at clinical remission. However, SAMIS and bone edema score in the biologics group were significantly lower than that in the nonbiologics group. Our results suggested that biologics treatment might be superior to nonbiologics treatment to suppress bone edema and to regulate subclinical inflammation.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64(2-4), 2014, p.119-126","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13575","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハスイ, ケイスケ"}]},{"nameIdentifiers":[{"nameIdentifier":"11691","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サクラバ, ヒロタケ"}]},{"nameIdentifiers":[{"nameIdentifier":"11686","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシグロ, ヨウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11498","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヒラガ, ヒロト"}]},{"nameIdentifiers":[{"nameIdentifier":"11181","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フクダ, シンサク"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13580","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"200000805","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/200000805_ja.html"}],"names":[{"name":"蓮井, 桂介"}]},{"nameIdentifiers":[{"nameIdentifier":"11683","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000163","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000163_ja.html"}],"names":[{"name":"櫻庭, 裕丈"}]},{"nameIdentifiers":[{"nameIdentifier":"11678","nameIdentifierScheme":"WEKO"}],"names":[{"name":"石黒, 陽"}]},{"nameIdentifiers":[{"nameIdentifier":"11489","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000578","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000578_ja.html"}],"names":[{"name":"平賀, 寛人"}]},{"nameIdentifiers":[{"nameIdentifier":"11172","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"226","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/226_ja.html"}],"names":[{"name":"福田, 眞作"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine / Department of Gastroenterology and Hematology, Hirosaki National Hospital, National Hospital Organization"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科消化器血液内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器血液内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器血液内科学講座 / 独立行政法人国立病院機構弘前病院消化器血液内科"},{"subitem_text_value":"弘前大学大学院医学研究科消化器血液内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器血液内科学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasui, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakuraba, Hirotake"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ishiguro, Yoh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiraga, Hiroto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Fukuda, Shinsaku"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64(2-4)_119.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64(2-4)_119.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3762/files/HirosakiMedJ_64(2-4)_119.pdf"},"version_id":"f50d4ec3-5020-4e77-ba3a-43643beed5f0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Rheumatoid arthritis","subitem_subject_scheme":"Other"},{"subitem_subject":"MRI","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical remission","subitem_subject_scheme":"Other"},{"subitem_subject":"subclinical inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"bone marrow edema","subitem_subject_scheme":"Other"},{"subitem_subject":"関節リウマチ","subitem_subject_scheme":"Other"},{"subitem_subject":"MRI","subitem_subject_scheme":"Other"},{"subitem_subject":"臨床的寛解","subitem_subject_scheme":"Other"},{"subitem_subject":"潜在的炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄浮腫","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Biologic Therapy Suppresses Subclinical Inflammation Identified by Magnetic Resonance Imaging in Rheumatoid Arthritis Patients in Clinical Remission State","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biologic Therapy Suppresses Subclinical Inflammation Identified by Magnetic Resonance Imaging in Rheumatoid Arthritis Patients in Clinical Remission State"}]},"item_type_id":"3","owner":"3","path":["653"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-28"},"publish_date":"2014-03-28","publish_status":"0","recid":"3762","relation_version_is_last":true,"title":["Biologic Therapy Suppresses Subclinical Inflammation Identified by Magnetic Resonance Imaging in Rheumatoid Arthritis Patients in Clinical Remission State"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:06:26.974955+00:00"}