{"created":"2023-05-15T09:02:52.839194+00:00","id":3766,"links":{},"metadata":{"_buckets":{"deposit":"1fe99324-bc8a-4d48-8b51-0308d7fbf436"},"_deposit":{"created_by":3,"id":"3766","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3766"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003766","sets":["557:561:653"]},"author_link":["13342","13671","12425","13664","13672","13665","12410","13677","13348","11191","13683","11731","13675","11181","13682","13346","13337","13676","11172","13687","11721","13340","12420","13668","13667","13680","11741","13663","13669","13336","13666","13686","13688"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"側方伸展型発育を示す早期大腸癌の組織学的特徴"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ソクホウ　シンテンガタ　ハツイク　オ　シメス　ソウキ　ダイチョウガン　ノ　ソシキガクテキ　トクチョウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"169","bibliographicPageStart":"158","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, laterally spreading tumor （LST） of early colorectal carcinoma has been treated by endoscopic submucosal dissection （ESD） more frequently. Many cases of early colorectal carcinomas are diagnosed as well differentiated adenocarcinomas, but histological and/or immunohistorogical heterogeneity is often seen in LSTs. In this study, we analyzed morphological characteristics of 61 lesions of LST-type early colorectal carcinoma by using histolosical and immunohistochemical procedures. Presence of high grade atypia components was significantly correlated with depth of submucosal invasion （P=0.0102）, and these were predominantly located to the invasive front（deep part） of the submucosal carcinoma. Allred scores of p53 and Ki-67 labeling indices were increased in the component of high grade atypia regardless of depth of invasion. Expressions of CDX2 and CD10 were significantly upregulated in a depth-of-invasion dependent manner, and these tended to be highly expressed in the high grade atypias. In onclusion, the present study indicates that the majority of LST is histologically heterogeneic. The component of high grade atypia of LST upregulates cell proliferation, which may leed to increase the malignant potential of LST for invading the submucosa.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64(2-4), 2014, p.158-169","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13669","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タカスギ, カオリ"}]},{"nameIdentifiers":[{"nameIdentifier":"13342","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モロハシ, サトコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13671","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハガ, トシヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"13672","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トバ, タカヒト"}]},{"nameIdentifiers":[{"nameIdentifier":"11731","nameIdentifierScheme":"WEKO"}],"names":[{"name":"セイノ, ヒロコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13340","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ゴ, ウンエン"}]},{"nameIdentifiers":[{"nameIdentifier":"13675","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スズキ, タカヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"13676","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナバタ, ノリヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"13677","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ササキ, ヨシヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11181","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フクダ, シンサク"}]},{"nameIdentifiers":[{"nameIdentifier":"12420","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キジマ, ヒロシ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13680","nameIdentifierScheme":"WEKO"}],"names":[{"name":"高杉, かおり"}]},{"nameIdentifiers":[{"nameIdentifier":"13348","nameIdentifierScheme":"WEKO"}],"names":[{"name":"諸橋, 聡子"}]},{"nameIdentifiers":[{"nameIdentifier":"13682","nameIdentifierScheme":"WEKO"}],"names":[{"name":"羽賀, 敏博"}]},{"nameIdentifiers":[{"nameIdentifier":"13683","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鳥羽, 崇仁"}]},{"nameIdentifiers":[{"nameIdentifier":"11721","nameIdentifierScheme":"WEKO"}],"names":[{"name":"清野, 浩子"}]},{"nameIdentifiers":[{"nameIdentifier":"13346","nameIdentifierScheme":"WEKO"}],"names":[{"name":"呉, 雲燕"}]},{"nameIdentifiers":[{"nameIdentifier":"13686","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鈴木, 貴弘"}]},{"nameIdentifiers":[{"nameIdentifier":"13687","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花畑, 憲洋"}]},{"nameIdentifiers":[{"nameIdentifier":"13688","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"518","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/518_ja.html"}],"names":[{"name":"佐々木, 賀広"}]},{"nameIdentifiers":[{"nameIdentifier":"11172","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"226","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/226_ja.html"}],"names":[{"name":"福田, 眞作"}]},{"nameIdentifiers":[{"nameIdentifier":"12425","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"208","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/208_ja.html"}],"names":[{"name":"鬼島, 宏"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.5","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine / Department of Gastroenterology and Hematology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine / Department of Gastroenterology and Hematology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Medical Informatics, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Departments of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座 / 弘前大学大学院医学研究科消化器血液内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座 / 弘前大学大学院医学研究科消化器血液内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器血液内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科医学医療情報学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器血液内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理生命科学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takasugi, Kaori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morohashi, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Haga, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toba, Takahito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seino, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wu, Yunyan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanabata, Norihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Yoshihiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Fukuda, Shinsaku"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kijima, Hiroshi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64(2-4)_158.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64(2-4)_158.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3766/files/HirosakiMedJ_64(2-4)_158.pdf"},"version_id":"47991da0-f495-48ff-8f6a-dc153161b526"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Colorectal cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"early cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"laterally spreading tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"endoscopic resection","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸・直腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"早期癌","subitem_subject_scheme":"Other"},{"subitem_subject":"側方伸展型腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"内視鏡的切除術","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histopathological Characteristics of Laterally Spreading Tumor（LST） Type Early Colorectal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histopathological Characteristics of Laterally Spreading Tumor（LST） Type Early Colorectal Cancer"}]},"item_type_id":"3","owner":"3","path":["653"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-28"},"publish_date":"2014-03-28","publish_status":"0","recid":"3766","relation_version_is_last":true,"title":["Histopathological Characteristics of Laterally Spreading Tumor（LST） Type Early Colorectal Cancer"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:56:12.105481+00:00"}