{"created":"2023-05-15T09:02:53.292147+00:00","id":3773,"links":{},"metadata":{"_buckets":{"deposit":"dc3422d4-072f-4318-9c67-30fef60dec47"},"_deposit":{"created_by":3,"id":"3773","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3773"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003773","sets":["557:561:654"]},"author_link":["13751","13746","13771","13743","13758","13755","13747","13764","13765","13741","13742","13761","11731","13753","13745","13744","13770","13748","13768","13754","13769","13759","13767","13766","13750","13752","13757","13756","13762","13772","13749","13760"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S27","bibliographicPageStart":"S19","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Since January 2011, we have started to a personalized medicine for controlled-release tacrolimus, once-daily oral formulation of tacrolimus, based on the CYP3A5 polymorphisms. Tacrolimus has a narrow therapeutic range, and its pharmacokinetics differs greatly among individuals. Many factors may affect the pharmacokinetics of tacrolimus, including CYP3A5 genotypes. Patients with CYP3A5*1 allele（ CYP3A5 expressers） require a higher daily tacrolimus dose than those with CYP3A5*3/*3 genotype （non-expressers） in order to maintain the target trough level. Recently, we investigated the increase in renal cortical interstitial fibrosis （IF） from 0-hour to 1-year posttransplantation using an automated digital analysis of biopsy sections and assessed the relative risk of developing IF based on clinical characteristics, laboratory data, tacrolimus-based immunosuppressive regimens, and the CYP3A5 polymorphism. In a multivariate analysis, CYP3A5 non-expression correlated with the development of IF. The mean tacrolimus trough concentrations in the early stages after transplantation were unexpectedly higher among non-expressers than CYP3A5 expressers, despite therapeutic drug monitoring. This unexpectedly high tacrolimus levels in non-expressers might influence the development of IF.\n　 Before staring the personalize medicine for controlled-release tacrolimus, we analyzed circadian pharmacokinetics and pharmacogenetics of twice daily tacrolimus, and its association with transplant outcome. We briefly reviewed our clinical research into tacrolimus.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64(Suppl.), 2013, p.S19-27","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13757","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サイトウ, シゲル"}]},{"nameIdentifiers":[{"nameIdentifier":"13758","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サイトウ, ミツル"}]},{"nameIdentifiers":[{"nameIdentifier":"13759","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヌマクラ, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"13760","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミウラ, ヨシオ"}]},{"nameIdentifiers":[{"nameIdentifier":"13761","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イノウエ, タカミツ"}]},{"nameIdentifiers":[{"nameIdentifier":"13762","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マイタ, シンヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"11731","nameIdentifierScheme":"WEKO"}],"names":[{"name":"セイノ, ヒロコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13764","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツルタ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"13765","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナリタ, シンタロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"13766","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ホリカワ, ヨウヘイ"}]},{"nameIdentifiers":[{"nameIdentifier":"13767","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツチヤ, ノリヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13768","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハブチ, トモノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"13769","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミトベ, ヨウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13770","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コマツダ, アツシ"}]},{"nameIdentifiers":[{"nameIdentifier":"13771","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カガヤ, ヒデアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"13772","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミウラ, マサトモ"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Urology, Replacement Therapeutic Science, Akita University School of Medicine"},{"subitem_text_value":"Division of Renal, Replacement Therapeutic Science, Akita University School of Medicine"},{"subitem_text_value":"Department of Nephrology and Rheumatology, Akita University School of Medicine"},{"subitem_text_value":"Department of Pharmacy, Akita University Hospital"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satoh, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Mitsuru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Numakura, Kazuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Yoshio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inoue, Takamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maita, Shinya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Obara, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuruta, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Narita, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horikawa, Yohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchiya, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Habuchi, Tomonori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitobe, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Komatsuda, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kagaya, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Masatomo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64_S19.pdf","filesize":[{"value":"284.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64_S19.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3773/files/HirosakiMedJ_64_S19.pdf"},"version_id":"3885ed40-a818-4569-87a5-951e7bf592bb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tacrolimus","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP3A5 polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"circadian exposure","subitem_subject_scheme":"Other"},{"subitem_subject":"interstitial fibrosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pharmacogenetics and Circadian exposure of Tacrolimus and Its Impact on the renal Transplant Outcome: A Way to a Personalized Medicine for Tacrolimus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pharmacogenetics and Circadian exposure of Tacrolimus and Its Impact on the renal Transplant Outcome: A Way to a Personalized Medicine for Tacrolimus"}]},"item_type_id":"3","owner":"3","path":["654"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-30"},"publish_date":"2013-04-30","publish_status":"0","recid":"3773","relation_version_is_last":true,"title":["Pharmacogenetics and Circadian exposure of Tacrolimus and Its Impact on the renal Transplant Outcome: A Way to a Personalized Medicine for Tacrolimus"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T11:46:06.136605+00:00"}