{"created":"2023-05-15T09:02:53.681153+00:00","id":3779,"links":{},"metadata":{"_buckets":{"deposit":"4e48cc74-f884-4809-a9ed-ea8085c9bfde"},"_deposit":{"created_by":3,"id":"3779","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3779"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003779","sets":["557:561:654"]},"author_link":["13814","11463","11447","13809","12519","13816","12411","13806","11451","13804","11458","7522","11449","11452","11871","7528","11459","13802","11456","7525","12421","11448"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S73","bibliographicPageStart":"S70","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Viral infection is important in renal pathology both as a trigger of chronic inflammatory diseases and as a complication associated with organ transplantation. Glomerular mesangial cells produce a variety of functional molecules potentially involved in immune reactions, and we investigated anti-viral responses in normal human mesangial cells. Human mesangial cells were treated with polyinosinic-polycytidylic acid （poly IC）, an authentic double-stranded RNA that mimics viral RNA. Treatment of cells with poly IC induced interferon-β （IFN-β）, retinoic acid-inducible gene-I（ RIG-I）, CC chemokine ligand 5（ CCL5）, differentiated embryo-chondrocyte 2（ DEC2） and IFN-stimulated gene 20 （ISG20）. Knockdown of toll-like receptor 3 （TLR3）, by RNA interference （RNAi）, abolished the poly IC-induced expression of these molecules. RNAi against IFN-β inhibited the induction of RIG-I,\nCCL5 and ISG20, but not of DEC2. Knockdown of RIG-I resulted in the reduced expression of CCL5. RNAi against DEC2 enhanced the poly IC-induced expression of IFN-β, RIG-I and CCL5. Transfection of cells with a poly IC/cationic lipid complex induced IFN-β, RIG-I and ISG20. Knockdown of RIG-I decreased the expression of IFN-β and ISG20 induced by transfection with poly IC/cationic lipid. TLR3 and RIG-I may function as recognition receptors against double-stranded RNA, which induce IFN-β and its downstream IFN-inducible genes. In the signaling elicited by poly IC, the IFN-inducible genes include RIG-I and effector molecules as CCL5 with leukocyte chemotactic activity and ISG20 with exonuclease activity on single-stranded RNA. The poly IC-induced expression of DEC2 is independent on IFN-β and it may control the signaling elicited by double-stranded RNA. The poly IC-inducible molecules may mediate anti-viral innate responses in renal mesangial cells.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64(Suppl.), 2013, p.S70-73","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11451","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イマイズミ, タダアツ"}]},{"nameIdentifiers":[{"nameIdentifier":"13806","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アイザワ, トモミ"}]},{"nameIdentifiers":[{"nameIdentifier":"7525","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タナカ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12421","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, フユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"13809","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ジン, フェイ"}]},{"nameIdentifiers":[{"nameIdentifier":"12519","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツミヤ, トモオ"}]},{"nameIdentifiers":[{"nameIdentifier":"11452","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシダ, ヒデミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11456","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, ケイ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11447","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"318","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/318_ja.html"}],"names":[{"name":"今泉, 忠淳"}]},{"nameIdentifiers":[{"nameIdentifier":"13814","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000694","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000694_ja.html"}],"names":[{"name":"相澤, 知美"}]},{"nameIdentifiers":[{"nameIdentifier":"7522","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"448","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/448_ja.html"}],"names":[{"name":"田中, 完"}]},{"nameIdentifiers":[{"nameIdentifier":"13816","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"319","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/319_ja.html"}],"names":[{"name":"松宮, 朋穂"}]},{"nameIdentifiers":[{"nameIdentifier":"11448","nameIdentifierScheme":"WEKO"}],"names":[{"name":"吉田, 秀見"}]},{"nameIdentifiers":[{"nameIdentifier":"11449","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 敬"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of School Health Science, Faculty of Education, Hirosaki University"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaizumi, Tadaatsu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Aizawa, Tomomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Fuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Xing, Fei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumiya, Tomoh"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshida, Hidemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Kei"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64_S70.pdf","filesize":[{"value":"232.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64_S70.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3779/files/HirosakiMedJ_64_S70.pdf"},"version_id":"04fef858-26fb-48bd-a910-dd1064e2d10b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"TLR3","subitem_subject_scheme":"Other"},{"subitem_subject":"FN-β","subitem_subject_scheme":"Other"},{"subitem_subject":"RIG-I","subitem_subject_scheme":"Other"},{"subitem_subject":"ISG20","subitem_subject_scheme":"Other"},{"subitem_subject":"DEC2","subitem_subject_scheme":"Other"},{"subitem_subject":"mesangial cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Innate Immune Reactions Against RNA Viruses in Renal Mesangial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Innate Immune Reactions Against RNA Viruses in Renal Mesangial Cells"}]},"item_type_id":"3","owner":"3","path":["654"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-30"},"publish_date":"2013-04-30","publish_status":"0","recid":"3779","relation_version_is_last":true,"title":["Innate Immune Reactions Against RNA Viruses in Renal Mesangial Cells"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:27:18.121701+00:00"}