{"created":"2023-05-15T09:02:53.811996+00:00","id":3781,"links":{},"metadata":{"_buckets":{"deposit":"43c6051c-44c9-4891-a71a-cf7d6d1dc779"},"_deposit":{"created_by":3,"id":"3781","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3781"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003781","sets":["557:561:654"]},"author_link":["13834","9403","12081","11869","13838","12076","12451","13830","9404","9399","9396","9397","12072","9400","12447"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S85","bibliographicPageStart":"S81","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Microscopic globular bodies （MGBs） are eosinophilic spherical inclusions, 1-10 μm in diameter and are located in dendrites. Although MGBs are distributed widely in the gray matter, they are most frequent and numerous in the cerebral neocortex and hippocampus. They are found in the human subjects with and without neurological diseases, ranging in age from 1 to 99 years. Previous histochemical studies have shown that MGBs consist of a proteinaceous component. Recently, we immunohistochemically examined the hippocampus from five control subjects. The marginal portion of MGBs was positive for lysosomal proteases（ cathepsins B, D and L）, and markers of dendrite（ MAP2） and dendritic spine（ drebrin）. They were negative for ubiquitin, ubiquitin-proteasome system （p62, NUB1 and EDD1）, autophagosome （LC3）, cytoskeletal proteins （neurofilament, actin, tubulin and cytokeratin）, tau, α-synuclein and TDP-43. These findings suggest that MGBs are sequestered by lysosome-protease\nsystem, but not by ubiquitin-proteasome system or autophagosome.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64(Suppl.), 2013, p.S81-S85","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12076","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オダギリ, サオリ"}]},{"nameIdentifiers":[{"nameIdentifier":"9400","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モリ, フミアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12447","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タンジ, クニカズ"}]},{"nameIdentifiers":[{"nameIdentifier":"13834","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クロダ, ナオヒト"}]},{"nameIdentifiers":[{"nameIdentifier":"9399","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ワカバヤシ, コウイチ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12081","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小田桐, 紗織"}]},{"nameIdentifiers":[{"nameIdentifier":"9397","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"313","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/313_ja.html"}],"names":[{"name":"森, 文秋"}]},{"nameIdentifiers":[{"nameIdentifier":"12451","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"314","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/314_ja.html"}],"names":[{"name":"丹治, 邦和"}]},{"nameIdentifiers":[{"nameIdentifier":"13838","nameIdentifierScheme":"WEKO"}],"names":[{"name":"黒田, 直人"}]},{"nameIdentifiers":[{"nameIdentifier":"9396","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"312","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/312_ja.html"}],"names":[{"name":"若林, 孝一"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Departments of Neuropathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Departments of Neuroanatomy, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Departments of Cell Biology and Histology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Departments of Forensic Medicine, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Odagiri, Saori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Fumiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanji, Kunikazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kuroda, Naohito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakabayashi, Koichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64_S81.pdf","filesize":[{"value":"223.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64_S81.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3781/files/HirosakiMedJ_64_S81.pdf"},"version_id":"ab8a121a-0a4e-487e-bdf5-4a7147fcfd6d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cathepsin","subitem_subject_scheme":"Other"},{"subitem_subject":"dendrite","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"lysosome-protease system","subitem_subject_scheme":"Other"},{"subitem_subject":"microscopic globular body","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Formation and Degradation of Microscopic Globular Body : A Proteinaceous Spheron Originated from Dendrite","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Formation and Degradation of Microscopic Globular Body : A Proteinaceous Spheron Originated from Dendrite"}]},"item_type_id":"3","owner":"3","path":["654"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-30"},"publish_date":"2013-04-30","publish_status":"0","recid":"3781","relation_version_is_last":true,"title":["Formation and Degradation of Microscopic Globular Body : A Proteinaceous Spheron Originated from Dendrite"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:07:07.625732+00:00"}