{"created":"2023-05-15T09:02:54.267050+00:00","id":3788,"links":{},"metadata":{"_buckets":{"deposit":"a5c11142-2440-4b96-a5eb-fc5e179293f4"},"_deposit":{"created_by":3,"id":"3788","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3788"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003788","sets":["557:561:654"]},"author_link":["13944","13972","13947","11589","11594","12860","11890","13958","13973","13381","13361","13961","11595","13956","13971","13949","13953","15487","11585","13969","13950","13959","11596","13943","13954","13946","12863","11586","13365","11583","11606","11607","11593","13377","13960","11584","13948","13951","13967","11610","15490","12858","11599"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-04-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S128","bibliographicPageStart":"S121","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background. Antibody-mediated rejection （AMR） after ABO-incompatible kidney transplantation （ABO-I KTx） is a major barrier to the success of transplantation. The advent of immunosuppressive therapy has markedly improved graft survival in ABO-I KTx. However, compare with a normal KTx, clinical conditions during ABO-IKTx are difficult to control due to over-immunosuppression. To reduce the immunosuppression we try to develop the blood group antigen-neutralizing therapy.\nMethods. We screened an ABO blood group antigen targeting peptide （BATP） by peptide library displayed T7 phage screening. After screening, a hemagglutination（ HA） inhibition assay and ELISA assay was used to analyze the blood group antigen blocking effect of the BATP. We also tested the inhibitory effect of anti-blood group Ab binding in normal human kidney tissues blocked with BATP.\nResults. We identified six peptide sequences. BATP efficiently suppresses hemagglutination of red blood cells caused by anti-ABO blood group antibodies and binding of these antibodies to ABO histo-blood group antigens on kidney tissue.\nConclusions. These data indicating that blood group A/B-antigen on RBCs and on kidney tissues may neutralize by BATP. This approach may enable the development of novel blood group antigen neutralizing therapy to overcome the challenges of ABO-I KTx.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64(Suppl.), 2013, p.S121-S128","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13954","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨネヤマ, トオル"}]},{"nameIdentifiers":[{"nameIdentifier":"13361","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハタケヤマ, シンゴ"}]},{"nameIdentifiers":[{"nameIdentifier":"13956","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマモト, ハヤト"}]},{"nameIdentifiers":[{"nameIdentifier":"12860","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イマニシ, ケンゴ"}]},{"nameIdentifiers":[{"nameIdentifier":"13958","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オカモト, テッペイ"}]},{"nameIdentifiers":[{"nameIdentifier":"13959","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トクイ, ノリコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13960","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スギヤマ, ナオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"13961","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スズキ, ユウイチロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"13365","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クドウ, シゲマサ"}]},{"nameIdentifiers":[{"nameIdentifier":"11593","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨネヤマ, タカヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11594","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハシモト, ヤスヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11595","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コイエ, タクヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"11596","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カミムラ, ノリタカ"}]},{"nameIdentifiers":[{"nameIdentifier":"13967","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フクダ, ミチコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11599","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオヤマ, チカラ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13969","nameIdentifierScheme":"WEKO"}],"names":[{"name":"米山, 徹"}]},{"nameIdentifiers":[{"nameIdentifier":"13377","nameIdentifierScheme":"WEKO"}],"names":[{"name":"畠山, 真吾"}]},{"nameIdentifiers":[{"nameIdentifier":"13971","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山本, 勇人"}]},{"nameIdentifiers":[{"nameIdentifier":"12858","nameIdentifierScheme":"WEKO"}],"names":[{"name":"今西, 賢悟"}]},{"nameIdentifiers":[{"nameIdentifier":"15487","nameIdentifierScheme":"WEKO"}],"names":[{"name":"岡本, 哲平"}]},{"nameIdentifiers":[{"nameIdentifier":"15490","nameIdentifierScheme":"WEKO"}],"names":[{"name":"得居, 範子"}]},{"nameIdentifiers":[{"nameIdentifier":"13972","nameIdentifierScheme":"WEKO"}],"names":[{"name":"杉山, 尚樹"}]},{"nameIdentifiers":[{"nameIdentifier":"13973","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鈴木, 裕一朗"}]},{"nameIdentifiers":[{"nameIdentifier":"13381","nameIdentifierScheme":"WEKO"}],"names":[{"name":"工藤, 茂将"}]},{"nameIdentifiers":[{"nameIdentifier":"11583","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"466","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/466_ja.html"}],"names":[{"name":"米山, 高弘"}]},{"nameIdentifiers":[{"nameIdentifier":"11584","nameIdentifierScheme":"WEKO"}],"names":[{"name":"橋本, 安弘"}]},{"nameIdentifiers":[{"nameIdentifier":"11585","nameIdentifierScheme":"WEKO"}],"names":[{"name":"古家, 琢也"}]},{"nameIdentifiers":[{"nameIdentifier":"11586","nameIdentifierScheme":"WEKO"}],"names":[{"name":"神村, 典孝"}]},{"nameIdentifiers":[{"nameIdentifier":"11589","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"272","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/272_ja.html"}],"names":[{"name":"大山, 力"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Advanced Transplantation & Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki"},{"subitem_text_value":"Oyokyo Kidney Research Institute, Hirosaki"},{"subitem_text_value":"Glycobiology Unit, Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoneyama, Tohru"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hatakeyama, Shingo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Hayato"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Imanishi, Kengo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Teppei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokui, Noriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugiyama, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Yuichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kudo, Shigemasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashimoto, Yasuhiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Koie, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamimura, Noritaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Michiko N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohyama, Chikara"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64_S121.pdf","filesize":[{"value":"309.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64_S121.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3788/files/HirosakiMedJ_64_S121.pdf"},"version_id":"bb81c5c6-c00d-4b19-b9e7-c49b29a7156e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Blood group antigen targeting peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"BATP","subitem_subject_scheme":"Other"},{"subitem_subject":"ABO-incompatible kidney transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"ABO-I KTx","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Blood Group Antigen Targeting Peptide Suppresses Thrombotic Microangiopathy in Renal Glomerular Capillaries after ABO-Incompatible Blood Reperfusion","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Blood Group Antigen Targeting Peptide Suppresses Thrombotic Microangiopathy in Renal Glomerular Capillaries after ABO-Incompatible Blood Reperfusion"}]},"item_type_id":"3","owner":"3","path":["654"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-30"},"publish_date":"2013-04-30","publish_status":"0","recid":"3788","relation_version_is_last":true,"title":["Blood Group Antigen Targeting Peptide Suppresses Thrombotic Microangiopathy in Renal Glomerular Capillaries after ABO-Incompatible Blood Reperfusion"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:55:54.911644+00:00"}