{"created":"2023-05-15T09:02:54.787194+00:00","id":3796,"links":{},"metadata":{"_buckets":{"deposit":"2ffbbf93-92cd-4183-9bdc-ac257d3985b1"},"_deposit":{"created_by":3,"id":"3796","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3796"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003796","sets":["557:561:655"]},"author_link":["11135","11618","11114","11118","11113","14121","14109","14103","11123","11116","14111","14108","11130","14120","14118","11131","11133","14102","11613","11122","14126","11125","14117","11127","11626"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"2型糖尿病患者において高インスリン血症は肥満，脂質異常症，インスリン抵抗性とは独立して血漿アルドステロン濃度上昇に関与している"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"2ガタ トウニョウビョウ カンジャ ニオイテ コウ インスリン ケッショウ ハ ヒマン シシツ イジョウショウ インスリン テイコウセイ トハ ドクリツ シテ ケッショウ アルドステロン ノウド ジョウショウ ニ カンヨ シテイル"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-04-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"42","bibliographicPageStart":"35","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The study was to define plasma insulin level with the association of renin-angiotensin-aldosterone system activity in patients with type 2 diabetes. One hundred fi fty type 2 diabetic patients and 24 non-diabetic subjects were studied. There was no statistical diff erence between the two groups in age, gender, the prevalence of hypertension, and serum potassium concentration. Plasma aldosterone concentration(PAC) was signifi cantly higher in type 2 diabetics than that in non-diabetic subjects(10.4±4.9 vs. 7.4±3.7 ng/dl；p=0.004)； however plasma renin activity(PRA) did not diff er signifi cantly between the two groups. In diabetic patients, PAC correlated signifi cantly with body mass index(BMI), fasting plasma insulin(F-IRI), homeostasis model assessment insulin resistance (HOMA-R), urinary C-peptide excretion(U-CPR), triglycerid(e TG), and high-density lipoprotein cholestero(l HDL-C). PRA correlated signifi cantly with F-IRI and HOMA-R, but did not correlate with BMI, U-CPR, TG, and HDL-C. The additional contribution of U-CPR in predicting PAC was signifi cant after adjustment for age, BMI, F-IRI, TG, HDL-C, and PRA(β=0.204, p=0.016). These fi ndings indicate that hyperinsulinemia may aff ect the increase in PAC unrelated with obesity, dyslipidemia, insulin resistance that are components of metabolic syndrome in patients with type 2 diabetes.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 65, 2014, p.35-42","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14109","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キムラ, ユウキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11127","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツイ, ジュン"}]},{"nameIdentifiers":[{"nameIdentifier":"14111","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツムラ, コウキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11122","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11618","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマシタ, マキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11125","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タナベ, ジュタロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11123","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タマサワ, ナオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"14117","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ダイモン, マコト"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14118","nameIdentifierScheme":"WEKO"}],"names":[{"name":"木村, 裕輝"}]},{"nameIdentifiers":[{"nameIdentifier":"11118","nameIdentifierScheme":"WEKO"}],"names":[{"name":"松井, 淳"}]},{"nameIdentifiers":[{"nameIdentifier":"14120","nameIdentifierScheme":"WEKO"}],"names":[{"name":"松村, 功貴"}]},{"nameIdentifiers":[{"nameIdentifier":"14121","nameIdentifierScheme":"WEKO"}],"names":[{"name":"村上, 洋"}]},{"nameIdentifiers":[{"nameIdentifier":"11626","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山下, 真紀"}]},{"nameIdentifiers":[{"nameIdentifier":"11116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000316","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000316_ja.html"}],"names":[{"name":"田辺, 壽太郎"}]},{"nameIdentifiers":[{"nameIdentifier":"11113","nameIdentifierScheme":"WEKO"}],"names":[{"name":"村上, 宏"}]},{"nameIdentifiers":[{"nameIdentifier":"11114","nameIdentifierScheme":"WEKO"}],"names":[{"name":"玉澤, 直樹"}]},{"nameIdentifiers":[{"nameIdentifier":"14126","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大門, 眞"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.123","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Diabetes and Endocrinology, Aomori City Hospital"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kimura, Yuki"}],"nameIdentifiers":[{"nameIdentifier":"14102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsui, Jun"}],"nameIdentifiers":[{"nameIdentifier":"11135","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumura, Koki"}],"nameIdentifiers":[{"nameIdentifier":"14103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"11130","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamashita, Maki"}],"nameIdentifiers":[{"nameIdentifier":"11613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanabe, Jutaro"}],"nameIdentifiers":[{"nameIdentifier":"11133","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamasawa, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"11131","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daimon, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"14108","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000660","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000660_ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_65(1)_35.pdf","filesize":[{"value":"908.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_65(1)_35.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3796/files/HirosakiMedJ_65(1)_35.pdf"},"version_id":"57cf7a87-6664-46d8-a0a4-516da9ebaa0a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"type 2 diabetes mellitus","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperinsulinemia","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"plasma renin activity","subitem_subject_scheme":"Other"},{"subitem_subject":"plasma aldosterone concentration","subitem_subject_scheme":"Other"},{"subitem_subject":"2型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"高インスリン血症","subitem_subject_scheme":"Other"},{"subitem_subject":"インスリン抵抗性","subitem_subject_scheme":"Other"},{"subitem_subject":"血漿レニン活性","subitem_subject_scheme":"Other"},{"subitem_subject":"血漿アルドステロン濃度","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hyperinsulinemia Leads the Elevation of Plasma Aldosterone Concentration Independently with Obesity, Dyslipidemia, and Insulin Resistance in Patients with Type 2 Diabetes Mellitus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hyperinsulinemia Leads the Elevation of Plasma Aldosterone Concentration Independently with Obesity, Dyslipidemia, and Insulin Resistance in Patients with Type 2 Diabetes Mellitus"}]},"item_type_id":"3","owner":"3","path":["655"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-05-22"},"publish_date":"2014-05-22","publish_status":"0","recid":"3796","relation_version_is_last":true,"title":["Hyperinsulinemia Leads the Elevation of Plasma Aldosterone Concentration Independently with Obesity, Dyslipidemia, and Insulin Resistance in Patients with Type 2 Diabetes Mellitus"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:34:22.738090+00:00"}