{"created":"2023-05-15T09:02:55.174392+00:00","id":3802,"links":{},"metadata":{"_buckets":{"deposit":"c74291ed-b3b8-42e9-9f1e-8ae648f8798e"},"_deposit":{"created_by":3,"id":"3802","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3802"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003802","sets":["557:561:655"]},"author_link":["13470","14190","14185","12641","12851","13457","13458","14197","13459","12844","12839","12639","12565","13463","12637","12570","12643","12640","13471","12562","12636"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Profiling of Rat Brain Peptides Treated with Centrally Active Ace Inhibitor"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"チュウスウ イコウガタ アンジオテンシン ヘンカン コウソ ソガイザイ トウヨ ニヨル ラット ノウナイ ペプチドセイ ブッシツ ノ プロファイィング"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-04-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"103","bibliographicPageStart":"95","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は，中枢移行性ACE 阻害剤（ACEI）による記憶保持亢進の機序を解明することである．中枢移行性ACEI（captopril），非中枢移行性ACEI （imidapril）およびARB（losartan）投与ラットでの脳内ペプチドの発現変化をHPLC 法およびTOF-MS 法を用いて検索した．その結果，TOF-MS 法では，captopril 投与群で特異的に発現が亢進するペプチドを多数検出できたが， その多くは質量数3,000以下であった．なお，これらの質量数はすべて一価イオンとして検出されたことから，すべて物質固有の質量数を反映していた．検出した質量数は，ACE が分解する脳内ペプチド（LH-RH,substance P, β-neoendorphin, neuromedin B, LVV-hemorphin-7, amyloid β-protein）やinsulin-regulated aminopeptidase（IRAP）の基質と考えられているvasopressin とは異なる値を示した．脳内にはACE やIRAP 以外にも活性中心にZn2+を有するメタロプロテアーゼが存在することから，今回得られた多くの質量数は，キレート形成能を有するcaptoprilにより阻害されたメタロプロテアーゼの内在性基質の可能性がある．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 65, 2014, p.95-103","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12639","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カナザワ, サチコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12641","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ホソイ, カズヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"テルイ, カズフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"12640","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シモヤマ, リツコ"}]},{"nameIdentifiers":[{"nameIdentifier":"14190","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカガワ, 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