{"created":"2023-05-15T09:02:55.755435+00:00","id":3811,"links":{},"metadata":{"_buckets":{"deposit":"6bf262d5-631c-468d-9e81-e29296840378"},"_deposit":{"created_by":3,"id":"3811","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3811"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003811","sets":["557:561:656"]},"author_link":["14227","12736","11977","14224","11982","11980","12747","14238","14230","14225","11875","11976","14237","14234","14231","14222","11987","11990","11983","11989","11994"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Coupling factor 6 の血管内皮細胞におけるケモカイン受容体発現に及ぼす影響"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"Coupling factor 6 ノ ケッカン ナイヒ サイボウ ニオケル ケモカイン ジュヨウタイ ハツゲン ニ オヨボス エイキョウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"127","bibliographicPageStart":"119","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract　Objectives: Vascular endothelial cells are exposed to an acidic pH, but its influence on chemokine receptors expressed in the vascular endothelial cells is unclear. We investigated the role of coupling factor 6 (CF6), a novel stimulator of proton importer, in the regulation of chemokine receptors in the vascular endothelial cells.\nMethods and Results: In microarray analysis, there were the increased expression of CC chemokine receptor 9 (CCR9) and CX3C chemokine receptor 1 (CX3CR1) and the decreased expression of CXC chemokine receptor 4 (CXCR4) in the human umbilical vascular endothelial cells (HUVEC) that were exposed to CF6. The ratio of CXCR4 to GAPDH mRNA was decreased in HUVEC that were exposed to either CF6 at 10-7M or hypoxia to a similar degree. Apoptotic cells, measured by annexin-V propidium iodide kit, were increased in HUVEC that were exposed to CF6 for 24 hours in normoxia.\nConclusions: CF6 influences the expression of chemokine receptors and induces apoptosis in the vascular endothelial cells.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 65(2-4), 2014, p.119-127","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14227","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スズキ, アキコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11983","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タナカ, マコト"}]},{"nameIdentifiers":[{"nameIdentifier":"14230","nameIdentifierScheme":"WEKO"}],"names":[{"name":"エンドウ, トモヒデ"}]},{"nameIdentifiers":[{"nameIdentifier":"14231","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ, カズオ"}]},{"nameIdentifiers":[{"nameIdentifier":"12736","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トミタ, ヒロフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14234","nameIdentifierScheme":"WEKO"}],"names":[{"name":"鈴木, 晃子"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"11990","nameIdentifierScheme":"WEKO"}],"names":[{"name":"田中, 真実"}]},{"nameIdentifiers":[{"nameIdentifier":"14237","nameIdentifierScheme":"WEKO"}],"names":[{"name":"遠藤, 知秀"}]},{"nameIdentifiers":[{"nameIdentifier":"14238","nameIdentifierScheme":"WEKO"}],"names":[{"name":"村上, 和男"}]},{"nameIdentifiers":[{"nameIdentifier":"12747","nameIdentifierScheme":"WEKO"}],"names":[{"name":"富田, 泰史"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.32","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Hypertension and Stroke Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Makoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Endo, Tomohide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Kazuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Hirofumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_65(2-4)_119.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_65(2-4)_119.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3811/files/HirosakiMedJ_65(2-4)_119.pdf"},"version_id":"e01f5aaf-3d59-42b5-a538-744629341ed0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"coupling factor 6","subitem_subject_scheme":"Other"},{"subitem_subject":"chemokine receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"vascular endothelial cells","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"カップリングファクター6","subitem_subject_scheme":"Other"},{"subitem_subject":"ケモカイン受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Coupling Factor 6 on Chemokine Receptors in Vascular Endothelial Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Coupling Factor 6 on Chemokine Receptors in Vascular Endothelial Cells"}]},"item_type_id":"3","owner":"3","path":["656"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-14"},"publish_date":"2014-11-14","publish_status":"0","recid":"3811","relation_version_is_last":true,"title":["Effect of Coupling Factor 6 on Chemokine Receptors in Vascular Endothelial Cells"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:42:35.636744+00:00"}