@article{oai:hirosaki.repo.nii.ac.jp:00003814,
 author = {Narita, Norihiko and Matsumiya, Tomoh and Kon, Takao and Hayakari, Ryo and Itoh, Ryohei and Kubota, Kosei and Sakaki, Hirotaka and Furudate, Ken and Yoshida, Hidemi and Imaizumi, Tadaatsu and Kobayashi, Wataru and Kimura, Hiroto},
 issue = {2-4},
 journal = {弘前医学},
 month = {Sep},
 note = {The CXC chemokine growth-related oncogene protein-α （GRO-α） has a wide variety of biological activities including as neutrophil trafficking or migration of vascular endothelial cells. In addition, studies have shown a crosstalk between tumor cells and vascular endothelial cells; GRO-α released by endothelial cells induces invasion of tumor cells toward endothelial cells, indicating an importance of GRO-α in a tumor environment. Oral squamous cells are reported to produce GRO-α in response to cytokines such as tumor necrosis factor-α （TNF-α）. However, little is known about how GRO-α is involved in oral cancer. Here, we investigated the biological role of GRO-α for both tumor growth and angiogenesis in oral squamous cell carcinoma cells. We first evaluated the effect of TNF-α on GRO-α expression in three oral cancer cells from different origins. Among the cell lines we used, KOSC-2 cells expressed the highest amount of GRO-α mRNA in response to TNF-α. TNF-α-treated condition medium from KOSC-2 cells enhanced endothelial cell chemotaxis and the chemotactic activity was partially inhibited by the addition of neutralizing anti-GRO-α antibody. In addition, GRO-α exerted tumor cell migration of KOSC-2. From these results, we conclude that GRO-α may contribute to both angiogenesis and proliferation in oral cancer., 弘前医学. 65(2-4), 2014, p.147-155},
 pages = {147--155},
 title = {Production of Growth-Related Oncogene Protein-α in a Human Oral Squamous Cell Carcinoma Cell Line Stimulated with Tumor Necrosis Factor-α: Role in Tumor Angiogenesis and Tumor Proliferation},
 volume = {65},
 year = {2014}
}