{"created":"2023-05-15T09:02:55.948854+00:00","id":3814,"links":{},"metadata":{"_buckets":{"deposit":"f1e7cd7e-615b-4d31-a126-ad7fb16d2b4e"},"_deposit":{"created_by":3,"id":"3814","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3814"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003814","sets":["557:561:656"]},"author_link":["14291","14318","14305","14298","11447","11870","14307","12519","11868","14293","14294","13816","14309","14312","14306","14295","11451","14311","11458","14310","14297","14313","14314","14300","11452","11871","14289","14299","14317","11459","14301","14292","14290","11876","14302","11448"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"培養ヒト口腔扁平上皮癌細胞におけるTNF-α依存的なGRO-αの誘導 : GRO-αによる血管新生作用と腫瘍増殖作用について"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"バイヨウ ヒト コウコウ ヘンペイ ジョウヒ ガン サイボウ ニオケル TNF-α イゾンテキナ GRO-α ノ ユウドウ GRO-α ニヨル ケッカン シンセイ サヨウ ト シュヨウ ゾウショク サヨウ ニツイテ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"155","bibliographicPageStart":"147","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The CXC chemokine growth-related oncogene protein-α （GRO-α） has a wide variety of biological activities including as neutrophil trafficking or migration of vascular endothelial cells. In addition, studies have shown a crosstalk between tumor cells and vascular endothelial cells; GRO-α released by endothelial cells induces invasion of tumor cells toward endothelial cells, indicating an importance of GRO-α in a tumor environment. Oral squamous cells are reported to produce GRO-α in response to cytokines such as tumor necrosis factor-α （TNF-α）. However, little is known about how GRO-α is involved in oral cancer. Here, we investigated the biological role of GRO-α for both tumor growth and angiogenesis in oral squamous cell carcinoma cells. We first evaluated the effect of TNF-α on GRO-α expression in three oral cancer cells from different origins. Among the cell lines we used, KOSC-2 cells expressed the highest amount of GRO-α mRNA in response to TNF-α. TNF-α-treated condition medium from KOSC-2 cells enhanced endothelial cell chemotaxis and the chemotactic activity was partially inhibited by the addition of neutralizing anti-GRO-α antibody. In addition, GRO-α exerted tumor cell migration of KOSC-2. From these results, we conclude that GRO-α may contribute to both angiogenesis and proliferation in oral cancer.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 65(2-4), 2014, p.147-155","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14295","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナリタ, ノリヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12519","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツミヤ, トモオ"}]},{"nameIdentifiers":[{"nameIdentifier":"14297","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コン, タカオ"}]},{"nameIdentifiers":[{"nameIdentifier":"14298","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハヤカリ, リョウ"}]},{"nameIdentifiers":[{"nameIdentifier":"14299","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, リョウヘイ"}]},{"nameIdentifiers":[{"nameIdentifier":"14300","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クボタ, コウセイ"}]},{"nameIdentifiers":[{"nameIdentifier":"14301","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サカキ, ヒロタカ"}]},{"nameIdentifiers":[{"nameIdentifier":"14302","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フルダテ, ケン"}]},{"nameIdentifiers":[{"nameIdentifier":"11452","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシダ, ヒデミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11451","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イマイズミ, タダアツ"}]},{"nameIdentifiers":[{"nameIdentifier":"14305","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コバヤシ, ワタル"}]},{"nameIdentifiers":[{"nameIdentifier":"14306","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キムラ, ヒロト"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14307","nameIdentifierScheme":"WEKO"}],"names":[{"name":"成田, 紀彦"}]},{"nameIdentifiers":[{"nameIdentifier":"13816","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"319","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/319_ja.html"}],"names":[{"name":"松宮, 朋穂"}]},{"nameIdentifiers":[{"nameIdentifier":"14309","nameIdentifierScheme":"WEKO"}],"names":[{"name":"今, 敬生"}]},{"nameIdentifiers":[{"nameIdentifier":"14310","nameIdentifierScheme":"WEKO"}],"names":[{"name":"早狩, 亮"}]},{"nameIdentifiers":[{"nameIdentifier":"14311","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 良平"}]},{"nameIdentifiers":[{"nameIdentifier":"14312","nameIdentifierScheme":"WEKO"}],"names":[{"name":"久保田, 耕世"}]},{"nameIdentifiers":[{"nameIdentifier":"14313","nameIdentifierScheme":"WEKO"}],"names":[{"name":"榊, 宏剛"}]},{"nameIdentifiers":[{"nameIdentifier":"14314","nameIdentifierScheme":"WEKO"}],"names":[{"name":"古舘, 健"}]},{"nameIdentifiers":[{"nameIdentifier":"11448","nameIdentifierScheme":"WEKO"}],"names":[{"name":"吉田, 秀見"}]},{"nameIdentifiers":[{"nameIdentifier":"11447","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"318","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/318_ja.html"}],"names":[{"name":"今泉, 忠淳"}]},{"nameIdentifiers":[{"nameIdentifier":"14317","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"309","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/309_ja.html"}],"names":[{"name":"小林, 恒"}]},{"nameIdentifiers":[{"nameIdentifier":"14318","nameIdentifierScheme":"WEKO"}],"names":[{"name":"木村, 博人"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"497.2","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"歯学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."},{"subitem_text_value":"Department of Dentistry and Oral Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan."}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Narita, Norihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumiya, Tomoh"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kon, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakari, Ryo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Ryohei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubota, Kosei"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sakaki, Hirotaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furudate, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Hidemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imaizumi, Tadaatsu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kobayashi, Wataru"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kimura, Hiroto"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_65(2-4)_147.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_65(2-4)_147.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3814/files/HirosakiMedJ_65(2-4)_147.pdf"},"version_id":"47647906-ca60-4559-b7c9-ba219903e388"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"growth-related oncogene protein-α(GRO-α)","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor-α(TNF-α)","subitem_subject_scheme":"Other"},{"subitem_subject":"oral squamous cell carcinoma cells","subitem_subject_scheme":"Other"},{"subitem_subject":"GRO-α","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍壊死因子（TNF-α）","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔扁平上皮癌","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Production of Growth-Related Oncogene Protein-α in a Human Oral Squamous Cell Carcinoma Cell Line Stimulated with Tumor Necrosis Factor-α: Role in Tumor Angiogenesis and Tumor Proliferation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Production of Growth-Related Oncogene Protein-α in a Human Oral Squamous Cell Carcinoma Cell Line Stimulated with Tumor Necrosis Factor-α: Role in Tumor Angiogenesis and Tumor Proliferation"}]},"item_type_id":"3","owner":"3","path":["656"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-14"},"publish_date":"2014-11-14","publish_status":"0","recid":"3814","relation_version_is_last":true,"title":["Production of Growth-Related Oncogene Protein-α in a Human Oral Squamous Cell Carcinoma Cell Line Stimulated with Tumor Necrosis Factor-α: Role in Tumor Angiogenesis and Tumor Proliferation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:27:19.198237+00:00"}