@article{oai:hirosaki.repo.nii.ac.jp:00003820,
 author = {Yakoshi, Yuta and Kudo, Daisuke and Toyoki, Yoshikazu and Ishido, Keinosuke and Kimura, Norihisa and Wakiya, Taiichi and Sakuraba, Shingo and Yoshizawa, Tadashi and Sakamoto, Yoshiyuki and Kijima, Hiroshi and Hakamada, Kenichi},
 issue = {2-4},
 journal = {弘前医学},
 month = {Sep},
 note = {Aim: Hepatic steatosis is a major cause of steatohepatitis and is observed in several diffuse liver diseases. We studied the efficacy of a novel ultrasound application, acoustic structure quantification （ASQ）, for analyzing the amount of fat deposition in the liver parenchyma. 
Methods: Forty-three patients who received a hepatectomy at our institution participated in this study. An ultrasound machine equipped with a software application for ASQ was used to detect steatosis prior to surgery. Non-tumoral liver parenchyma obtained by hepatectomy was pathologically evaluated according to the three-grade system. 
Results: Histopathologically, twenty-three patients did not present steatosis, seventeen presented grade 1, and the remaining three presented grade 2 steatosis. The median “focal disturbance ratio”（ FD-ratio）, a representative index obtained by ASQ, decreased with the steatosis grade, from 0.157（ range: 0.039-0.410） at steatosis grade 0, 0.085（ range: 0.021-0.159） at steatosis grade 1, and 0.039（ range: 0.021-0.048） at steatosis grade 2. There were significant differences in the FD-ratio between steatosis grades 0 and 1 and between steatosis grades 0 and 2 （p = 0.001 and p = 0.007, respectively）.
Conclusions: ASQ can be useful during a quantitative examination of the fat accumulation in the liver parenchyma and offers a reliable marker for the early detection of liver injury., 弘前医学. 65(2-4), 2014, p.199-208},
 pages = {199--208},
 title = {Non-Invasive Quantification of Liver Damage by a Novel Application for Statistical Analysis of Ultrasound Signals},
 volume = {65},
 year = {2014}
}