@article{oai:hirosaki.repo.nii.ac.jp:00003822,
 author = {Murakami, Manabu and Nemoto, Takayuki and Niwa, Hidetoshi and Kushikata, Tetsuya and Ono, Kyoichi and Watanabe, Hiroyuki and Hirota, Kazuyoshi and Ohba, Takayoshi},
 issue = {2-4},
 journal = {弘前医学},
 month = {Sep},
 note = {Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.
Main Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.
Key findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.
Significance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal
medulla., 弘前医学. 65(2-4), 2014, p.218-226},
 pages = {218--226},
 title = {Involvement of Endothelin-1 in Adrenal Catecholamine Regulation},
 volume = {65},
 year = {2014}
}