{"created":"2023-05-15T09:02:56.414479+00:00","id":3822,"links":{},"metadata":{"_buckets":{"deposit":"d19db640-7aa8-43cc-b3a2-9eb5fd9c1db5"},"_deposit":{"created_by":3,"id":"3822","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3822"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003822","sets":["557:561:656"]},"author_link":["14442","14792","14439","14443","14444","14440","14438","11861"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"226","bibliographicPageStart":"218","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims: The purpose of the current study was to evaluate the significance of the endothelin system in catecholamine release and synthesis in the adrenal gland.\nMain Methods: Primary cultures of isolated bovine adrenal medullary cells were prepared. Gene expression, intracellular calcium changes, epinephrine release, and other factors were investigated.\nKey findings: Expression of endothelin receptors in the rat adrenal gland was confirmed. Intravenous infusion of endothelin-1 (1.0 nmol) increased blood pressure (systolic and diastolic). Endothelin-1 stimulated intracellular calcium changes, resulting in increased nuclear factor of T cell (NFAT) activity and epinephrine release from cultured adrenal medullary cells. Furthermore, endothelin-1 increased catecholamine synthesis and caused hypertrophic changes in the cell size.\nSignificance: Our findings indicate involvement of the endothelin system in the sympathetic regulation of the adrenal\nmedulla.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 65(2-4), 2014, p.218-226","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"499","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"薬学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pharmacology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan"},{"subitem_text_value":"Department of Pharmacology, Graduate School of Medicine, University of Miyazaki 5200 Kihara Kiyotake Miyazaki, 889-1692, Japan"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan"},{"subitem_text_value":"Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan"},{"subitem_text_value":"Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine, Akita, 010-8543, Japan"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University, Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan"},{"subitem_text_value":"Department of Cellphysiology, Akita University School of Medicine, Akita, 010-8543, Japan"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Murakami, Manabu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nemoto, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niwa, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kushikata, Tetsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ono, Kyoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirota, Kazuyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ohba, Takayoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_65(2-4)_218.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_65(2-4)_218.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3822/files/HirosakiMedJ_65(2-4)_218.pdf"},"version_id":"f54ed2bd-2d08-434a-8808-8dd5943f67a7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adrenal gland","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium","subitem_subject_scheme":"Other"},{"subitem_subject":"catecholamine","subitem_subject_scheme":"Other"},{"subitem_subject":"blood pressure","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Involvement of Endothelin-1 in Adrenal Catecholamine Regulation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of Endothelin-1 in Adrenal Catecholamine Regulation"}]},"item_type_id":"3","owner":"3","path":["656"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-11-14"},"publish_date":"2014-11-14","publish_status":"0","recid":"3822","relation_version_is_last":true,"title":["Involvement of Endothelin-1 in Adrenal Catecholamine Regulation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:58:49.066619+00:00"}