{"created":"2023-05-15T09:02:57.440499+00:00","id":3839,"links":{},"metadata":{"_buckets":{"deposit":"2ef5c98b-29b1-45f1-a37c-57dbac7b175f"},"_deposit":{"created_by":3,"id":"3839","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3839"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003839","sets":["557:561:657"]},"author_link":["14442","14792","14516","11517","14444","14440","11458","14438","10562","11861"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"21","bibliographicPageStart":"15","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We compared the effects of inhalation anesthesia（ 2% isoflurane）, intraperitoneal injection of pentobarbital anesthesia （50 mg/kg）, and a combination anesthetic consisting of medetomidine, midazolam and butorphanol （MMB） on electrocardiograms in mice. Using either isoflurane inhalation anesthesia or pentobarbital anesthesia, heart rate （HR） was in the acceptable range （ca. 450-500 bpm）. In contrast, MMB anesthesia decreased HR significantly. Importantly, MMB anesthesia responded minimally to propranolol （β-blocker）, suggesting that MMB anesthesia affects sympathetic tonus and is not suitable for evaluation of the cardiovascular or sympathetic system. We confirmed that modified MMB, with a decreased dose of medetomidine from the original protocol（ an α2 agonist）, was associated with a HR of 400 bpm and a diminished response to propranolol. Our present results illustrate the importance of using an appropriate form of anesthesia suitable for experimental pharmacological studies.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 66, 2015, p.15-21","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pharmacology,Hirosaki University Graduate School ofedicine"},{"subitem_text_value":"Department of Cell Physiology, Akita University, Graduate School of Medicine"},{"subitem_text_value":"Department of Anesthesiology ,Hirosaki University Graduate School ofedicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Graduate School ofedicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Graduate School ofedicine"},{"subitem_text_value":"Department of Cell Physiology, Akita University, Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School ofedicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School ofedicine"},{"subitem_text_value":"Department of Pharmacology Hirosaki University Graduate School ofedicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shintaku, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Takayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niwa, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kushikata, Tetsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hirota, Kazuyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ono, Kyoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mariya, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imaizumi, Tadaatsu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sawamura, Daisuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Murakami, Manabu"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_66(1)_15.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_66(1)_15.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3839/files/HirosakiMedJ_66(1)_15.pdf"},"version_id":"8f73cd1a-c912-4439-a191-3d823045f456"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"inhalation anesthesia","subitem_subject_scheme":"Other"},{"subitem_subject":"isoflurane","subitem_subject_scheme":"Other"},{"subitem_subject":"propofol","subitem_subject_scheme":"Other"},{"subitem_subject":"pentobarbital","subitem_subject_scheme":"Other"},{"subitem_subject":"medetomidine","subitem_subject_scheme":"Other"},{"subitem_subject":"midazolam","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison of the Effects of Isoflurane Inhalation, Pentobarbital and a Medetomidine-Midazolam-Butorphanol Combination Anesthesia on Electrocardiograms in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison of the Effects of Isoflurane Inhalation, Pentobarbital and a Medetomidine-Midazolam-Butorphanol Combination Anesthesia on Electrocardiograms in Mice"}]},"item_type_id":"3","owner":"3","path":["657"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-25"},"publish_date":"2015-05-25","publish_status":"0","recid":"3839","relation_version_is_last":true,"title":["Comparison of the Effects of Isoflurane Inhalation, Pentobarbital and a Medetomidine-Midazolam-Butorphanol Combination Anesthesia on Electrocardiograms in Mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:51:00.962320+00:00"}