{"created":"2023-05-15T09:02:57.704499+00:00","id":3845,"links":{},"metadata":{"_buckets":{"deposit":"2158d60b-0081-41ce-a0af-33cf756fec6a"},"_deposit":{"created_by":3,"id":"3845","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3845"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003845","sets":["557:561:657"]},"author_link":["13308","11764","13310","11138","11762","14108","12054"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"72","bibliographicPageStart":"65","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chronic pancreatitis is histopathologically characterized by the progression of pancreatic fibrosis. Pancreatic stellate cells （PSCs） play a principal role in the development of pancreatic fibrosis. Tranilast suppresses collagen synthesis of fibroblasts derived from keloid hypertrophic scars and cell proliferation of fibroblasts. Hence, we hypothesize that tranilast suppresses fibrosis and is effective against pancreatic fibrosis. In this study, we examined the effect of tranilast on cell proliferation, activation, and collagen synthesis of cultured PSCs. Tranilast significantly inhibited the proliferation of PSCs when they were cultured with and without of platelet-derived growth factor （PDGF） and decreased the expression of alpha smooth muscle actin（ α-SMA） in cultures with Transforming Growth Factor-β1 （TGF-β1） and PDGF. Tranilast did not cause a significant dose-dependent reduction in the amount of collagen in the medium. Neither did it significantly affect the expression of Col-1 mRNA compared to the control. Our results suggest that tranilast inhibits the development of pancreatic fibrosis, making it a potential therapeutic agents for chronic pancreatitis.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 66, 2015, p.65-72","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Medical Life Science, Hirosaki University Graduate School of Health Science"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Health Care Center Hirosaki Medical Association"},{"subitem_text_value":"Aomori Rosai Hospital"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chikazawa, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tando, Yusuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Matsuhashi, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagimachi, Miyuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nakamura, Teruo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Daimon, Makoto"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_66(1)_65.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_66(1)_65.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3845/files/HirosakiMedJ_66(1)_65.pdf"},"version_id":"7b4ff5cc-b05a-42d3-8e59-4a4f1e5400c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"alpha smooth muscle actin","subitem_subject_scheme":"Other"},{"subitem_subject":"platelet-derived growth factor","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic stellate cells","subitem_subject_scheme":"Other"},{"subitem_subject":"　Transforming Growth Factor-β1","subitem_subject_scheme":"Other"},{"subitem_subject":"tranilast","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tranilast Inhibits Proliferation of Pancreatic Stellate Cells and Activation of Pancreatic Fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tranilast Inhibits Proliferation of Pancreatic Stellate Cells and Activation of Pancreatic Fibrosis"}]},"item_type_id":"3","owner":"3","path":["657"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-25"},"publish_date":"2015-05-25","publish_status":"0","recid":"3845","relation_version_is_last":true,"title":["Tranilast Inhibits Proliferation of Pancreatic Stellate Cells and Activation of Pancreatic Fibrosis"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:51:49.291979+00:00"}