{"created":"2023-05-15T09:02:58.322862+00:00","id":3859,"links":{},"metadata":{"_buckets":{"deposit":"35ceb724-015b-4826-9349-289fec5a5eb4"},"_deposit":{"created_by":3,"id":"3859","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3859"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003859","sets":["557:561:658"]},"author_link":["16028","14589","14588","12657","14587","12647"],"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"GABAA ジュヨウタイ オウトウ　ノ　セイギョ　キコウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"109","bibliographicPageStart":"105","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"γ -aminobutyric acid （GABA）は成熟脳における主要な抑制性神経伝達物質であり，対応する受容体としてGABAA およびGABAB 受容体が存在する．GABAA受容体はGABA が結合することによりCl- イオンに選択性をもつイオンチャネルで，神経細胞膜電位の過分極をきたし，最終的に活動電位発生抑制をもたらす．このGABA 作動性の抑制機構はダイナミックに制御されていることが近年明らかとなってきた．この制御メカニズムを，①細胞内Cl- 濃度制御，②GABAA 受容体サブユニット発現による制御，③受容体分布にかかわる受容体輸送（トラフィッキング）機構に焦点をあてて紹介する．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 66, 2016, p.105-109","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科脳神経生理学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上野, 伸哉"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"古川, 智範"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"二階堂, 義和"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"下山, 修司"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"柴, 祐子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 順子"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_66(2-4)_105.pdf","filesize":[{"value":"848.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_66(2-4)_105.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3859/files/HirosakiMedJ_66(2-4)_105.pdf"},"version_id":"ca3ac24e-7a2f-4122-81b0-46fc5292b92c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"受容体発現による機能調節","subitem_subject_scheme":"Other"},{"subitem_subject":"神経部位ごとの発現調節.","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"GABAA 受容体応答の制御機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"GABAA 受容体応答の制御機構"}]},"item_type_id":"3","owner":"3","path":["658"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-31"},"publish_date":"2016-03-31","publish_status":"0","recid":"3859","relation_version_is_last":true,"title":["GABAA 受容体応答の制御機構"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:34:35.906706+00:00"}