{"created":"2023-05-15T09:02:58.547596+00:00","id":3864,"links":{},"metadata":{"_buckets":{"deposit":"a4a17b3c-fb35-45a0-9f6d-666a6d77eb52"},"_deposit":{"created_by":3,"id":"3864","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3864"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003864","sets":["557:561:658"]},"author_link":["14616","14615","14614","12955","14613","11191","12262"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"151","bibliographicPageStart":"143","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background & Aims: Liver fibrosis progresses to cirrhosis as the consequence of chronic liver injury. 4-methylumbelliferone （4-MU）, a derivative of coumarin, has been used as an approved drug to treat biliary spasm. Recent publications have reported that 4-MU inhibits production of hyaluronan （HA）, which is a key component of extracellular matrix deposition in fibrotic and cirrhotic liver. We investigated the effect of 4-MU on fibrotic liver in rats. \nMethods: Liver fibrosis was induced by bile duct ligation（ BDL）. Male Sprague-Dawley rats received a standard diet or the same diet containing 1% or 5% of 4-MU from 1 week before BDL. The rats were sacrificed at 3 weeks after BDL. \nResults: Administration of 4-MU increased serum 4-MU concentration levels, thereby decreasing serum HA levels in a dose-dependent manner. 4-MU treatment suppressed liver fibrosis in interlobular and pericentral areas with reduced alpha-smooth muscle actin expression, which suggested hepatic stellate cell activation.\nConclusion: Treatment with 4-MU suppressed the experimental hepatic fibrosis accompanied by inhibition of HA production. Although further experimental studies are needed, 4-MU could protect against fibrogenesis and may be repurposed as a safe therapeutic application for hepatic fibrosis.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 66, 2016, p.143-151","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine"},{"subitem_text_value":"Department of Glycotechnology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sawada, Naoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mikami, Kenichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Igarashi, Go"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Tetsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Ken"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kakizaki, Ikuko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Fukuda, Shinsaku"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_66(2-4)_143.pdf","filesize":[{"value":"970.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_66(2-4)_143.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3864/files/HirosakiMedJ_66(2-4)_143.pdf"},"version_id":"60d683a1-756b-4cb3-a53d-5274774cbbe5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"liver fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"hyaluronan","subitem_subject_scheme":"Other"},{"subitem_subject":"4-methylumbelliferone","subitem_subject_scheme":"Other"},{"subitem_subject":"alpha-smooth muscle actin","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatic stellate cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Beneficial Effect of 4-Methylumbelliferone Against Bile Duct Ligation-Induced Hepatic Fibrosis in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Beneficial Effect of 4-Methylumbelliferone Against Bile Duct Ligation-Induced Hepatic Fibrosis in Rats"}]},"item_type_id":"3","owner":"3","path":["658"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-31"},"publish_date":"2016-03-31","publish_status":"0","recid":"3864","relation_version_is_last":true,"title":["Beneficial Effect of 4-Methylumbelliferone Against Bile Duct Ligation-Induced Hepatic Fibrosis in Rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:19:11.809482+00:00"}