{"created":"2023-05-15T09:02:59.288933+00:00","id":3877,"links":{},"metadata":{"_buckets":{"deposit":"308f88e1-97bd-4dc5-a83e-b048270b6e13"},"_deposit":{"created_by":3,"id":"3877","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3877"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003877","sets":["557:561:659"]},"author_link":["15967","14671","14668","13600","15963","14672","11855","14055","14673"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"13","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There are certain sex differences in the prevalence and severity of immunity-related diseases. Previous\nstudies have shown the influence of sex steroid hormones, such as estrogen and testosterone, on the immune system.\nThe aim of this study was to investigate the association of sex steroid hormones with neutrophil function among\nnormal healthy subjects in the general population. Subjects included 540 residents（ 358 males and 182 females）, who\nparticipated in the Iwaki Health Promotion Project in 2014. We examined the association of estradiol and testosterone\nwith neutrophil ROS production and phagocytic activity. As a result, estradiol and testosterone negatively correlated\nwith basal ROS production in males and luteal phase females （>15th day of menstrual cycle）, although such trend\nwas not observed in follicular phase females（ <14th day of menstrual cycle） and postmenopausal females. In contrast,\nthe association of testosterone with stimulated ROS production and phagocytic activity was observed only in males.\nIn conclusion, both estradiol and testosterone were found to have an influence on neutrophil function. Furthermore,\nthe association of sex steroid hormones with neutrophil function was found to vary according to the phase of the menstrual cycle in addition to the sex difference.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 67, 2016, p.13-27","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cancer Epidemiology and Community Health, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"15963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komame, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"14668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akimoto, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"14055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sawada, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"13600","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000522","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000522_ja.html"}]},{"creatorNames":[{"creatorName":"Tanaka, Rina"}],"nameIdentifiers":[{"nameIdentifier":"14671","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Munakata, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"14672","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iizuka, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"14673","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"15967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakaji, Shigeyuki"}],"nameIdentifiers":[{"nameIdentifier":"11855","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_67(1)_13.pdf","filesize":[{"value":"161.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_67(1)_13.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3877/files/HirosakiMedJ_67(1)_13.pdf"},"version_id":"1385bdc5-8021-4db1-9228-9cb74c019d4f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sex steroid hormones","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive oxygen species","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_scheme":"Other"},{"subitem_subject":"general population","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association of Sex Steroid Hormones wth Neutrophil Function in the General Population","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of Sex Steroid Hormones wth Neutrophil Function in the General Population"}]},"item_type_id":"3","owner":"3","path":["659"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-05"},"publish_date":"2016-08-05","publish_status":"0","recid":"3877","relation_version_is_last":true,"title":["Association of Sex Steroid Hormones wth Neutrophil Function in the General Population"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:54:32.848435+00:00"}