{"created":"2023-05-15T09:02:59.355532+00:00","id":3878,"links":{},"metadata":{"_buckets":{"deposit":"b20d98e5-9a35-4585-8782-c4a1b2f1d344"},"_deposit":{"created_by":3,"id":"3878","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3878"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003878","sets":["557:561:659"]},"author_link":["12410","14682","13664","14680","14683","13337","14681","14679","14410","11191"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"38","bibliographicPageStart":"28","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Early biliary tract carcinomas（ BTCs） are divided into three groups: early gallbladder carcinoma（ GBC）,\nearly extrahepatic bile duct carcinoma （EBC）, and early duodenal ampullary carcinoma （DAC）. These early\ncarcinomas frequently show metaplastic changes. However, phenotypic characterization has not yet been examined.\nWe examined 76 lesions of surgically resected early biliary tract carcinomas （pTis/pT1 tumors according to TNM\nclassification）. The predominant carcinoma phenotypes were classified with hematoxylin and eosin （HE） stain, and\nimmunohistochemical examinations （MUC1, MUC2, MUC5AC, MUC6, and CD10） were performed. We also analyzed\nphenotypes of the surrounding non-neoplastic mucosa. Of the 33 early GBCs, 18 （54.5%） were biliary type, and 15\n（45.5%） were metaplastic type （gastric foveolar type/intestinal type） carcinoma. Of the 26 early EBCs, 18 （69.2%）\nwere biliary type carcinoma, and eight（ 30.8%） were metaplastic type carcinoma. Of the 17 early DACs, eight（ 47.1%）\nwere biliary type carcinoma, nine （52.9%） were metaplastic type carcinoma. Biliary type carcinomas less frequently\nshowed metaplastic changes, while metaplastic type carcinomas were frequently surrounded by the metaplastic\nmucosa. Early GBC and early DAC more frequently showed metaplastic changes, compared to the early EBC. In\nconclusion, we speculated that two carcinogenesis pathways of early BTC （GBC, EBC, and DAC）: （1） carcinomas\narising from the proper epithelium （mainly EBC） and （2） carcinomas from the metaplastic epithelium （mainly GBC and DAC）.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 67, 2016, p.28-38","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Medical Oncology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Gastroenterology, Hirosaki UniversityGraduates School of Medicine"},{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Gastroenterology, Hirosaki UniversityGraduates School of Medicine"},{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki University Graduates School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Haga, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshizawa, Tadashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morohashi, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirai, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saitou, Kensuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Rie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takatsuna, Masafumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wu, Yuyan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Shinsaku"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kijima, Hiroshi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_67(1)_28.pdf","filesize":[{"value":"742.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_67(1)_28.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3878/files/HirosakiMedJ_67(1)_28.pdf"},"version_id":"f1449daa-3f78-4c11-892e-4c53ba7b532a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Early biliary tract carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"carcinogenesis","subitem_subject_scheme":"Other"},{"subitem_subject":"metaplasia","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Phenotypic Characterization of Early Biliary Tract Carcinomas Proposes Two Carcinogenesis Pathways","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Phenotypic Characterization of Early Biliary Tract Carcinomas Proposes Two Carcinogenesis Pathways"}]},"item_type_id":"3","owner":"3","path":["659"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-05"},"publish_date":"2016-08-05","publish_status":"0","recid":"3878","relation_version_is_last":true,"title":["Phenotypic Characterization of Early Biliary Tract Carcinomas Proposes Two Carcinogenesis Pathways"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:10:02.383915+00:00"}