{"created":"2023-05-15T09:02:59.684489+00:00","id":3883,"links":{},"metadata":{"_buckets":{"deposit":"a4a76dcc-54d4-4832-a842-a90d2a000eee"},"_deposit":{"created_by":3,"id":"3883","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3883"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003883","sets":["557:561:659"]},"author_link":["14442","14792","14702","14443","14701","14444","14440","11458","14438","11861"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"85","bibliographicPageStart":"77","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Transgenic mice experiments have become increasingly popular to research human inherited disease.\nHowever, a number of Japanese researchers have difficulty with the selection of anesthesia, after the classification\nof ketamine, probably the most used anesthesia, as a narcotic drug in 2006. Therefore, we compared the effects of\ninhalation anesthesia （2% of isoflurane, sevoflurane and enflurane） and intraperitoneal pentobarbital anesthesia （50\nmg/kg） on the electrocardiogram（ ECG） and blood oxygen saturation（ SPO2） of mice. With inhalation anesthesia, the\nheart rate（ HR） and SPO2 were within an acceptable range. In contrast, the HR significantly decreased after initiation\nof pentobarbital anesthesia, and gradually returned to a low rate. Importantly, pentobarbital anesthesia significantly\nlowered SPO2, and heart rate variability analysis showed unstable beat-to-beat intervals during pentobarbital\nanesthesia, suggesting that inhalation anesthesia is more suitable for evaluation of cardiorespiratory responses\nthan pentobarbital anesthesia. During anesthesia, propranolol, a ????-adrenergic blocker, significantly decreased heart\nrate. Atropine, a parasympathetic blocker, also significantly increased heart rate. Our data suggest that inhalation 　anesthesia is suitable for cardiorespiratory analysis in mice.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 67, 2016, p.77-85","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pharmacology, Hirosaki UniversityGraduates School of Medicine"},{"subitem_text_value":"Department of Pharmacology, Hirosaki UniversityGraduates School of Medicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Internal Medicine Division of Cardiovascular and Respiratory Medicine, Akita University School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Graduates School of Medicine"},{"subitem_text_value":"Department of Cellphysiology, Akita University School of Medicine"},{"subitem_text_value":"Department of Cellphysiology, Akita University School of Medicine"},{"subitem_text_value":"Department of Pharmacology, Hirosaki UniversityGraduates School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chong, Han"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogata, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niwa, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kushikata, Tetsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imaizumi, Tadaatsu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hirota, Kazuyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ono, Kyoichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Takayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Manabu"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_67(1)_77.pdf","filesize":[{"value":"329.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_67(1)_77.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3883/files/HirosakiMedJ_67(1)_77.pdf"},"version_id":"be8b725d-f6e5-46d1-a134-7f0a19ab94d9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Inhalation isoflurane anesthesia","subitem_subject_scheme":"Other"},{"subitem_subject":"pentobarbital","subitem_subject_scheme":"Other"},{"subitem_subject":"hemodynamic status","subitem_subject_scheme":"Other"},{"subitem_subject":"blood gas","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Cardiorespiratory Responses to Inhalation and Pentobarbital Anesthesia in the Mouse","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Cardiorespiratory Responses to Inhalation and Pentobarbital Anesthesia in the Mouse"}]},"item_type_id":"3","owner":"3","path":["659"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-05"},"publish_date":"2016-08-05","publish_status":"0","recid":"3883","relation_version_is_last":true,"title":["The Cardiorespiratory Responses to Inhalation and Pentobarbital Anesthesia in the Mouse"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:58:52.026446+00:00"}