{"created":"2023-05-15T09:03:00.659361+00:00","id":3898,"links":{},"metadata":{"_buckets":{"deposit":"2e3833d6-2065-435d-83b9-83c16569880a"},"_deposit":{"created_by":3,"id":"3898","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3898"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003898","sets":["557:561:660"]},"author_link":["14785","11512"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"128","bibliographicPageStart":"115","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Autophagy, a cellular homeostatic pathway, is emerged as an innate immune response against intracellular\npathogens. It can directly eliminate invading bacteria by mediating their delivery to lysosomes. However, successful\nintracellular pathogens have developed mechanism（s） to escape or subvert autophagy for their intracellular niches.\nStudies on interplay between autophagy and intracellular pathogens are very important for understanding how\ninfections occur. Particularly, Staphylococcus aureus is an important opportunistic pathogen that causes a wide range\nof infections. Classically, S. aureus is considered as an extracellular pathogen, but cumulative evidence indicates that\nthis bacterium invades epithelial cells and replicates intracellularly which is relevant to intracellular persistence and\nchronic infections. A serious therapeutic problem of staphylococcal infections is caused by antibiotic resistant strains\nwhich have emerged increasingly in recent years. Thus, new insights in the strategy of S. aureus to interplay with\nautophagy is urgently required. This review highlights an impact of S. aureus toxins on autophagy. Alpha-hemolysin\nactivates autophagy and prevents lysosome-autophagosome fusion, whereas toxic shock syndrome toxin-1 suppresses\nautophagosome formation. This opposite function indicates a complicated relationship between autophagy and\nintracellular adaptation of S. aureus. The possible effects of these toxins on S. aureus infections are also addressed in this review.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 67, 2017, p.115-128","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Asano, Krisana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_67(2-4)_115.pdf","filesize":[{"value":"870.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_67(2-4)_115.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3898/files/HirosakiMedJ_67(2-4)_115.pdf"},"version_id":"4785040a-6c0f-4e90-8ec1-73028097094a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Staphylococcus aureus","subitem_subject_scheme":"Other"},{"subitem_subject":"autophagy","subitem_subject_scheme":"Other"},{"subitem_subject":"intracellular pathogens","subitem_subject_scheme":"Other"},{"subitem_subject":"toxic shock syndrome toxin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"alpha-hemolysin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interplay Between Autophagy and Pathogenic Bacteria : Toxins Secreted by Staphylococcus Aureus and Their Impact","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interplay Between Autophagy and Pathogenic Bacteria : Toxins Secreted by Staphylococcus Aureus and Their Impact"}]},"item_type_id":"3","owner":"3","path":["660"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-09"},"publish_date":"2017-03-09","publish_status":"0","recid":"3898","relation_version_is_last":true,"title":["Interplay Between Autophagy and Pathogenic Bacteria : Toxins Secreted by Staphylococcus Aureus and Their Impact"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:58:58.812677+00:00"}