{"created":"2023-05-15T09:03:00.786594+00:00","id":3900,"links":{},"metadata":{"_buckets":{"deposit":"9df17d79-1067-4dbd-b45d-f1981b31e511"},"_deposit":{"created_by":3,"id":"3900","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3900"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003900","sets":["557:561:660"]},"author_link":["14805","12570","14336","14331","12844","14190","12565","14185","12641","14812","14811","12851","13459","14804"],"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"バイオシミラー　セイザイ　サイヨウ　ニ　ムケタ　バイオ　イヤクヒん　ノ　アンゼンセイ　ユウコウセイ　ノ　ヒョウカ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"146","bibliographicPageStart":"136","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究ではバイオ医薬品の純度について検討し，その安全性を評価することを目的とした。\n　糖鎖の付加がない単純タンパクである顆粒球コロニー刺激因子（granulocyte-colony stimulating factor, G-CSF）製剤\nでは，バイオシミラー（ 2 社製）も含め純度について比較検討した．その結果，SDS-PAGE 法，HPLC 法，SELDI-TOF\nMS 法において，先行品およびバイオシミラーは高純度のG-CSF を含んでいることが明らかとなり，安全性は問題がな\nいことが明らかとなった。\n　また，バイオ医薬品の1 つであるキメラ型抗体製剤（infliximab）のエピトープマッピングを行い，投与患者に産生され\nる中和抗体に対する抗原部位を検索した．その結果，少なくとも3 箇所に抗原部位を認め，中和抗体のマルチタイプの検索が今後の薬物療法への重要な指標となることを明らかにした。","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 67, 2017, p.136-146","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14336","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツヤマ, ヒロマサ"}]},{"nameIdentifiers":[{"nameIdentifier":"14190","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカガワ, ジュンイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"12641","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ホソイ, カズヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"テルイ, カズフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"14811","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヒョウドウ, ルイ"}]},{"nameIdentifiers":[{"nameIdentifier":"14812","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ウエノ, カヨ"}]},{"nameIdentifiers":[{"nameIdentifier":"12565","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハヤカリ, マコト"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部，弘前大学大学院医学研究科薬剤学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"津山, 博匡"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中川, 潤一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"細井, 一広"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"照井, 一史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"兵藤, 塁"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上野, 桂代"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"早狩, 誠"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_67(2-4)_136.pdf","filesize":[{"value":"649.6 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