@article{oai:hirosaki.repo.nii.ac.jp:00003902,
 author = {Ogata, Yoshiki and Yonekura, Manabu and Yamaki, Rouichi and Han, Chong and Fujiwara, Tomonori and Seya, Kazuhiko and Niwa, Hidetoshi and Kushikata, Tetsuya and Imaizumi, Tadaatsu and Hirota, Kazuyoshi and Tomita, Hirofumi and Murakami, Manabu},
 issue = {2-4},
 journal = {弘前医学},
 month = {Feb},
 note = {We examined the effects of enflurane anesthesia on the mouse cardiac autonomic nervous system using
electrocardiogram（ ECG） analysis. Enflurane had a lower effect on heart rate（ HR） compared to isoflurane, which is
more widely used in small animal studies. Under anesthesia with 3 or 4% of enflurane, administration of propranolol
had a significant effect on HR. Enflurane increased R-R interval length in a dose-dependent fashion, and the R-R
interval became unstable at high concentrations. Although HR decreased with high doses of enflurane, we observed
normal sinus rhythm and no arrhythmia. These results suggest that the effect of enflurane anesthesia is acceptable
even though the drug can lead to cardiac instability. No remarkable changes were observed in HR frequency. These results suggest that enflurane anesthesia may be suitable for cardiac autonomic nervous system analysis., 弘前医学. 67, 2017, p.153-157},
 pages = {153--157},
 title = {Effects of Enflurane on Cardiac Autonomic Nervous Activity in Mice},
 volume = {67},
 year = {2017}
}