@article{oai:hirosaki.repo.nii.ac.jp:00003921,
 author = {Nishimura, Masayuki and Tsubo, Toshihito and Hirota, Kazuyoshi},
 issue = {1},
 journal = {弘前医学},
 month = {Oct},
 note = {B-lines are the important signs of pulmonary edema in acute respiratory distress syndrome
（ARDS） detected with ultrasonography. We studied the mechanism of the origin and disappearance of B-lines in
ARDS piglets using ultrasonography and microscopy.
Methods: ARDS was induced by intratracheal administration of 0.1M Hydrochloric Acid （HCl） in 23 anesthetized,
ventilated piglets. The occurrence of B-lines was evaluated using transthoracic echography （TTE） and
transesophageal echography （TEE）. Changes in B-lines were recorded after a saline infusion into the pleural space,
and after pulmonary consolidation developed and reached the pleura. Left lower lobe was excised and lung sections
were examined by light microscopy.
Results: Following the saline infusion into the pleural space, we observed B-lines fanning out from the visceral
pleura. As pulmonary consolidation developed, B-lines disappeared. The structure that B-lines fanned out from was
the complex of thickened pleura and sub-pleural interlobular septa surrounded by gas. In the tissue where B-lines
disappeared, the thickened sub-pleural interlobular septa were surrounded by cells and liquid.
Conclusions: We found that B-lines derive from the complex of thickened pleura and sub-pleural interlobular septa
surrounded by gas. B-lines disappeared when the sub-pleural thickened interlobular septa were surrounded by cells and liquid., 弘前医学. 68, p.14-22. 2017},
 pages = {14--22},
 title = {What is Happening in The Ards Piglet Lungs: - The Origin of B-Lines on Ultrasonography -},
 volume = {68},
 year = {2017}
}