{"created":"2023-05-15T09:03:02.326433+00:00","id":3923,"links":{},"metadata":{"_buckets":{"deposit":"734406dc-ce36-43da-8945-d2db520801fe"},"_deposit":{"created_by":3,"id":"3923","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3923"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003923","sets":["557:561:661"]},"author_link":["14789","14792","13470","14790","14702","15009","14444","11844","14440","15019","11980","14438","11861","15015"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"43","bibliographicPageStart":"33","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Persistent hyperglycemia is implicated in the pathogenesis of chronic diabetic complications, such as\nneuropathy. Therefore, we investigated Electrocardiogram（ ECG）-related changes, including various ECG parameters\nand heart rate variability, and neuropathic changes in diabetic Goto-Kakizaki （GK） rats, a spontaneous model for\ntype 2 diabetes. GK rats （50 weeks old） showed increased plasma glucose and decreased R-R interval variability,\nwhich was likely due to diabetic polyneuropathy in the autonomic nervous system. Interestingly, GK rats showed a\ndecreased baroreflex compared with control Wistar rats. Furthermore, GK rats showed limited fluctuation changes\nin beat-to-beat dynamics. In the frequency domain analysis, the low-frequency component was similar but the highfrequency\ncomponent was significantly decreased in GK rats, suggesting decreased parasympathetic nerve regulation\nand conserved sympathetic nerve regulation. In addition, GK rats showed a limited response to high-dose atropine, a\nmuscarinic receptor antagonist, indicating modified parasympathetic nerve regulation in GK rats. Our data strongly\nsuggests that GK rat could be a nice animal model for chronic cardiovascular disease related to diabetic neuropathy.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 68, p.33-43. 2017","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pharmacology"},{"subitem_text_value":"Department of Pathology and Molecular Medicine"},{"subitem_text_value":"Department of Cardiology"},{"subitem_text_value":"Department of Pharmacology"},{"subitem_text_value":"Department of Cellphysiology, Akita University School of Medicine, Akita"},{"subitem_text_value":"Department of Anesthesiology"},{"subitem_text_value":"Department of Anesthesiology"},{"subitem_text_value":"Department of MolecularPharmacology, Tohoku University School of Medicine"},{"subitem_text_value":"Department of Cardiology"},{"subitem_text_value":"Department of Pharmacy, Hirosaki University, Graduate School of Medicine"},{"subitem_text_value":"Department of Anesthesiology"},{"subitem_text_value":"Department of Metabolism and Diabetes, Tohoku Medical Pharmaceutical University"},{"subitem_text_value":"Department of Pathology and Molecular Medicine"},{"subitem_text_value":"Department of Pharmacology"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Han, Chong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaba, Wataru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yonekura, Manabu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogata, Yoshiki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohba, Takayoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kushikata, Tetsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Niwa, Hidetoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yanagisawa, Teruyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Hirofumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Itagaki, Shirou"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirota, Kazuyoshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Akai, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizukami, Hiroki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Murakami, Manabu"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_68(1)_33.pdf","filesize":[{"value":"397.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_68(1)_33.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3923/files/HirosakiMedJ_68(1)_33.pdf"},"version_id":"ba7af50f-d60b-47d3-b485-de3a2fa3c08a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"rats","subitem_subject_scheme":"Other"},{"subitem_subject":"ECG","subitem_subject_scheme":"Other"},{"subitem_subject":"parasympathetic nerve","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes mellitus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats"}]},"item_type_id":"3","owner":"3","path":["661"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-23"},"publish_date":"2017-10-23","publish_status":"0","recid":"3923","relation_version_is_last":true,"title":["Modified Parasympathetic Nervous System in Goto-Kakizaki Diabetic Rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:20:25.953792+00:00"}