@article{oai:hirosaki.repo.nii.ac.jp:00003926,
 author = {Igarashi, Go and Sawada, Naoya and Kimura, Masayo and Endo, Tetsu and Fukuda, Shinsaku},
 issue = {1},
 journal = {弘前医学},
 month = {Oct},
 note = {Hyaluronan plays a role not only as a structural component but also in the
regulation of inflammatory processes. However, the role of hyaluronan in acute pancreatitis is not clear. In this study,
we have explored the role of hyaluronan in a rat acute pancreatitis model using a hyaluronan synthesis inhibitor,
4-methylumbelliferone（ 4-MU）. Methods: Six-week-old male Sprague-Dawley rats were fed a standard diet or the same
diet containing 5% 4-MU beginning two weeks before induction of cerulean- and lipopolysaccharide-induced acute
pancreatitis. The severity of acute pancreatitis and pro-inflammatory cytokine levels were evaluated with or without
pretreatment with 4-MU. Results: Before development of acute pancreatitis, 4-MU pretreatment reduced serum
hyaluronan levels. After development of acute pancreatitis, 4-MU pretreatment increased serum amylase level and blood
urea nitrogen/creatinine ratio. However, 4-MU pretreatment suppressed tumor necrosis factor-α （TNF- α） production in
acute pancreatitis. Conclusions: Systemic inhibition of hyaluronan exacerbated acute pancreatitis in spite of suppression
of TNF-α production. These data suggest that hyaluronan has two completely different effects, i.e., a barrier function
and as a regulator of inflammation in acute pancreatitis. The results emphasize that further analysis that takes into account the molecular size of hyaluronan is needed since it may explain the contradictory findings., 弘前医学. 68, p.62-70. 2017},
 pages = {62--70},
 title = {Two Contradictory Roles of Hyaluronan in an Experimental Rat Acute Pancreatitis Model},
 volume = {68},
 year = {2017}
}