{"created":"2023-05-15T09:03:02.537039+00:00","id":3926,"links":{},"metadata":{"_buckets":{"deposit":"befc4063-b570-4f6f-ae0a-c5e265352f7e"},"_deposit":{"created_by":3,"id":"3926","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3926"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003926","sets":["557:561:661"]},"author_link":["15031","14616","14615","14613","11191"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"70","bibliographicPageStart":"62","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyaluronan plays a role not only as a structural component but also in the\nregulation of inflammatory processes. However, the role of hyaluronan in acute pancreatitis is not clear. In this study,\nwe have explored the role of hyaluronan in a rat acute pancreatitis model using a hyaluronan synthesis inhibitor,\n4-methylumbelliferone（ 4-MU）. Methods: Six-week-old male Sprague-Dawley rats were fed a standard diet or the same\ndiet containing 5% 4-MU beginning two weeks before induction of cerulean- and lipopolysaccharide-induced acute\npancreatitis. The severity of acute pancreatitis and pro-inflammatory cytokine levels were evaluated with or without\npretreatment with 4-MU. Results: Before development of acute pancreatitis, 4-MU pretreatment reduced serum\nhyaluronan levels. After development of acute pancreatitis, 4-MU pretreatment increased serum amylase level and blood\nurea nitrogen/creatinine ratio. However, 4-MU pretreatment suppressed tumor necrosis factor-α （TNF- α） production in\nacute pancreatitis. Conclusions: Systemic inhibition of hyaluronan exacerbated acute pancreatitis in spite of suppression\nof TNF-α production. These data suggest that hyaluronan has two completely different effects, i.e., a barrier function\nand as a regulator of inflammation in acute pancreatitis. The results emphasize that further analysis that takes into account the molecular size of hyaluronan is needed since it may explain the contradictory findings.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 68, p.62-70. 2017","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Igarashi, Go"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawada, Naoya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kimura, Masayo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Tetsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Shinsaku"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_68(1)_62.pdf","filesize":[{"value":"461.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_68(1)_62.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3926/files/HirosakiMedJ_68(1)_62.pdf"},"version_id":"e9eca3f0-1a0d-40a4-99f3-344ef99194e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hyaluronan; 4-methylumbelliferone","subitem_subject_scheme":"Other"},{"subitem_subject":"acute pancreatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"pro-inflammatory cytokine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Two Contradictory Roles of Hyaluronan in an Experimental Rat Acute Pancreatitis Model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Two Contradictory Roles of Hyaluronan in an Experimental Rat Acute Pancreatitis Model"}]},"item_type_id":"3","owner":"3","path":["661"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-23"},"publish_date":"2017-10-23","publish_status":"0","recid":"3926","relation_version_is_last":true,"title":["Two Contradictory Roles of Hyaluronan in an Experimental Rat Acute Pancreatitis Model"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:19:13.147754+00:00"}