{"created":"2023-05-15T09:03:14.137265+00:00","id":4118,"links":{},"metadata":{"_buckets":{"deposit":"1e27f5bd-b0a1-4406-bc8d-f964b41d4571"},"_deposit":{"created_by":3,"id":"4118","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4118"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004118","sets":["557:666:669"]},"author_link":["14558","12506","15650","15655","12507","12509","12508","15645","12558","15651","14557"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"374","bibliographicPageStart":"368","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Translational Stroke Research"}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-09-30"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Rho/Rho-kinase pathway is considered important in the pathogenesis of sustained smooth muscle cell contraction during cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). The aims of this study were to investigate whether combination treatment, with pitavastatin as an inhibitor of RhoA and fasudil as an inhibitor of Rho-kinase, prevents the cerebral vasospasm. SAH was simulated using the double-hemorrhage rabbit model, and pitavastatin, or fasudil, or both (combination treatment) were administrated. The basilar artery (BA) cross-sectional area only in the combination treatment group was statistically larger than in the SAH group (p < 0.05). BA Rho-kinase, as measured by ELISA, was statistically reduced only in the combination treatment group compared with the SAH group (p < 0.05). In the other two treatment groups, pitavastatin or fasudil treatment group showed larger BA cross-sectional areas and lower value for BA Rho-kinase, but there were no statistically significant differences compared with the SAH group. The expression of endothelial nitric oxide synthase (eNOS), evaluated by immunohistochemistry in the pitavastatin group and the combination group, was higher than in the SAH group. Results indicate that combination treatment could extensively prevent cerebral vasospasm due to the synergic effect of combining pitavastatin and fasudil on the Rho/Rho-kinase pathway and on eNOS.","subitem_description_type":"Abstract"}]},"item_7_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Open Access Article","subitem_description_type":"Other"}]},"item_7_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Translational Stroke Research, 4(3), 2013, p.368-374","subitem_description_type":"Other"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1807"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15650","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナラオカ, マサト"}]},{"nameIdentifiers":[{"nameIdentifier":"15651","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムナカタ, アキラ"}]},{"nameIdentifiers":[{"nameIdentifier":"14557","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツダ, ナオヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"12508","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シマムラ, ノリヒト"}]},{"nameIdentifiers":[{"nameIdentifier":"12509","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオクマ, ヒロキ"}]}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15655","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"486","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/486_ja.html"}],"names":[{"name":"奈良岡, 征都"}]}]},"item_7_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer"}]},"item_7_radio_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"ETD"}]},"item_7_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Thesis"}]},"item_7_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12975-012-0247-9","subitem_relation_type_select":"DOI"}}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12507752","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1868-4483","subitem_source_identifier_type":"ISSN"}]},"item_7_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.62","subitem_subject_scheme":"NDC"}]},"item_7_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neurosurgery, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8216, Japan"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naraoka, Masato"}],"nameIdentifiers":[{"nameIdentifier":"15645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Munakata, Akira"}],"nameIdentifiers":[{"nameIdentifier":"12558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuda, Naoya"}],"nameIdentifiers":[{"nameIdentifier":"14558","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimamura, Norihito"}],"nameIdentifiers":[{"nameIdentifier":"12506","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"298","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/298_ja.html"}]},{"creatorNames":[{"creatorName":"Ohkuma, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"12507","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1807_naraoka_a1.pdf","filesize":[{"value":"187.6 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kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4118/files/tdm_1807_naraoka_a2.pdf"},"version_id":"4eb59730-e82a-4767-a678-e9860e380bc9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cerebral vasospasm","subitem_subject_scheme":"Other"},{"subitem_subject":"Pitavastatin","subitem_subject_scheme":"Other"},{"subitem_subject":"Fasudil","subitem_subject_scheme":"Other"},{"subitem_subject":"Rho/Rho-kinase pathway","subitem_subject_scheme":"Other"},{"subitem_subject":"eNOS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit"}]},"item_type_id":"7","owner":"3","path":["669"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-20"},"publish_date":"2013-12-20","publish_status":"0","recid":"4118","relation_version_is_last":true,"title":["Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:03:33.508556+00:00"}