{"created":"2023-05-15T09:03:14.827641+00:00","id":4134,"links":{},"metadata":{"_buckets":{"deposit":"4e42dbc6-ad77-42ec-bc85-fb336e2ab56d"},"_deposit":{"created_by":3,"id":"4134","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4134"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004134","sets":["557:666:670"]},"author_link":["14231","14225","14238"],"item_7_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ホスリパーゼC-δ1活性亢進下でのアセチルコリン誘発性カルシウム流入におけるプロテインキナーゼCの役割"}]},"item_7_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ホスリパーゼC-δ1 カッセイ コウシンカ デノ アセチルコリン ユウハツセイ カルシウム リュウニュウ ニオケル プロテインキナーゼC ノ ヤクワリ"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"22","bibliographicVolumeNumber":"66","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-24"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"冠攣縮性狭心症患者の皮膚線維芽細胞においてphospholipase C(PLC)-δ1活性は\n亢進しており、PLC-δ1過剰発現マウスでは冠攣縮が誘発されることを報告した。\n今回我々はPLC-δ1過剰発現下で、アセチルコリン誘発性カルシウム流入におけ\nるprotein kinase C(PKC)の役割についてhuman embryonic kidney 293細胞を用い\nて検討した。アセチルコリン誘発性カルシウム流入はPLC-δ1過剰発現並びに\nPKCの抑制により優位に増加し，PKCの活性化により減少した。ニフェジピン\n存在下でのアセチルコリン誘発性カルシウム流入もPLC-δ1過剰発現並びに\nPKCの抑制により増加した。PKCはアセチルコリン誘発性カルシウム流入に対\nして負に作用し，ニフェジピン投与の影響をほとんど受けないことが示唆され\nた。","subitem_description_type":"Abstract"}]},"item_7_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"http://repository.ul.hirosaki-u.ac.jp/dspace/handle/10129/5559","subitem_description_type":"Other"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1876"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14231","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ, 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access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Murakami, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"14225","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1876_murakami.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://hirosaki.repo.nii.ac.jp/record/4134/files/tdm_1876_murakami.pdf"},"version_id":"fa3c9454-0351-4566-9660-3439891595ed"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1876_murakami_a2.pdf","filesize":[{"value":"453.1 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influx under enhanced phospholipase C-δ1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of protein kinase C in acetylcholine-induced Ca2+ influx under enhanced phospholipase C-δ1"}]},"item_type_id":"7","owner":"3","path":["670"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-21"},"publish_date":"2015-07-21","publish_status":"0","recid":"4134","relation_version_is_last":true,"title":["Role of protein kinase C in acetylcholine-induced Ca2+ influx under enhanced phospholipase C-δ1"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:14:33.805010+00:00"}