{"created":"2023-05-15T09:03:15.969704+00:00","id":4159,"links":{},"metadata":{"_buckets":{"deposit":"8d70a20f-3a83-4000-9114-a7f3b728d2a3"},"_deposit":{"created_by":3,"id":"4159","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4159"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004159","sets":["557:666:671"]},"author_link":["15907","15723","15900","15908","14559","14200","14561","15009","11844","16011","15901","14560","15720","15906","11842"],"item_7_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"2型糖尿病患者におけるアミロイド沈着は膵島内にマクロファージの浸潤を伴いβ細胞の減少と関連する"}]},"item_7_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"2ガタ トウニョウビョウ カンジャ ニオケル アミロイド チンチャク ワ スイトウ ナイ ニ マクロファージ ノ シンジュン オ トモナイ βサイボウ ノ ゲンショウ ト カンレンスル"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"201","bibliographicPageStart":"191","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Amyloid"}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-09-30"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims: Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical features and development of islet pathology is still unclear.\nMethods: From 118 autopsy cases with type 2 diabetes, 26 cases with islet amyloid deposition (DA+) were selected. Twenty diabetic subjects without obvious amyloid deposition (DA ) matched for the age and diabetes duration and 20 non-diabetic subjects (ND) served for comparison. We examined the severity of amyloid deposition and its relationships with population of endocrine cells, expression of cell damage markers or macrophage infiltration. Correlation of clinical profile with islet pathology was also sought on the subset of the investigated patients.\nResults: b-Cell volume density was nearly 40% less in DA+ and 20% less in DA  when compared to ND. Severity of amyloid deposition correlated with reduced volume densities of b-cell and a-cell, and increased body mass index (BMI), but not with duration of diabetes, age or HbA1c. Amyloid-rich islets contained an increased number of macrophages mixed with b-cells with oxidative stress-related DNA damage, characterized by gH2AX expression, and suppressed (pro)insulin mRNA expression.\nConclusions: In Japanese type 2 diabetic patients, islet amyloid was more common with severe b-cell loss and high BMI, associated with macrophage infiltration.","subitem_description_type":"Abstract"}]},"item_7_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Amyloid, 2014, 21(3), p.191-201","subitem_description_type":"Other"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1862"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14560","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カマタ, コウスケ"}]},{"nameIdentifiers":[{"nameIdentifier":"14200","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミズカミ, ヒロキ"}]},{"nameIdentifiers":[{"nameIdentifier":"15720","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イナバ, ワタル"}]},{"nameIdentifiers":[{"nameIdentifier":"15906","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツボイ, ケンタロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"15907","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タケイシ, ヨシノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"15908","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシダ, タロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"15723","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤギハシ, ソウロク"}]}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"14559","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"200000547","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/200000547_ja.html"}],"names":[{"name":"鎌田, 耕輔"}]}]},"item_7_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Informa healthcare"}]},"item_7_radio_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"ETD"}]},"item_7_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Thesis"}]},"item_7_relation_12":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"25007035","subitem_relation_type_select":"PMID"}}]},"item_7_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3109/13506129.2014.937857","subitem_relation_type_select":"DOI"}}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11096426","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1350-6129","subitem_source_identifier_type":"ISSN"}]},"item_7_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.123","subitem_subject_scheme":"NDC"}]},"item_7_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kamata, Kosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizukami, Hiroki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Inaba, Wataru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuboi, Kentaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tateishi, Yoshinori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Taro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yagihashi, Soroku"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_kamata_a2.pdf","filesize":[{"value":"97.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4159/files/tdm_kamata_a2.pdf"},"version_id":"7e9ee77e-d51c-439e-b516-b25c235e21ac"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_kamata_a1.pdf","filesize":[{"value":"168.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4159/files/tdm_kamata_a1.pdf"},"version_id":"92d3ecfc-56f2-45c1-9667-ae2de6afe5d2"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1862_kamata.pdf","filesize":[{"value":"909.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://hirosaki.repo.nii.ac.jp/record/4159/files/tdm_1862_kamata.pdf"},"version_id":"391cb26a-a0b5-4c97-81ef-aebe46cbd268"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"b-cell loss","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"morphometry","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic islet","subitem_subject_scheme":"Other"},{"subitem_subject":"type 2 diabetes","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients"}]},"item_type_id":"7","owner":"3","path":["671"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-19"},"publish_date":"2014-12-19","publish_status":"0","recid":"4159","relation_version_is_last":true,"title":["Islet amyloid with macrophage migration correlates with augmented b-cell deficits in type 2 diabetic patients"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:59:09.368527+00:00"}