{"created":"2023-05-15T09:03:18.197904+00:00","id":4210,"links":{},"metadata":{"_buckets":{"deposit":"25f22f2c-6c57-4242-a039-e10ed329542a"},"_deposit":{"created_by":3,"id":"4210","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4210"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004210","sets":["557:666:673"]},"author_link":["16028","16026","16027"],"item_7_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒト常染色体優性夜間前頭葉てんかん由来ニコチン性アセチルコリン受容体 β2 サブユニット変異ラットの自発性発作"}]},"item_7_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒト ジョウセンショクタイ ユウセイ ヤカン ゼントウヨウ テンカン ユライ ニコチンセイ アセチルコリン ジュヨウタイ β2 サブユニット ヘンイ ラット ノ ジハツセイ ホッサ"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"33","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-30"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We generated a transgenic rat strain with a missense mutation in V286L (V286L-TG),in the gene encoding the neuronal nicotinic acetylcholine receptor β2 subunit(CHRNB2) found in patients with autosomal dominant nocturnal frontal lobe epilepsy(ADNFLE). To confirm that V286L-TG rats exhibit seizures similar to those observed in humans, gene expression patterns and behavioral phenotypes were analyzed. In situhybridization using a V286L Chrnb2-selective probe indicated that the transgene was expressed at higher levels in the cortex, hippocampus, and cerebellum of V286L-TG than wild-type littermates (non-TG). Spontaneous epileptic seizures with ictal discharges in electroencephalograms were detected in 45% of V286L-TG rats and the\nfrequency of seizures was 0.73 times a week. This seizure type is similar to “paroxysmal arousals” that are observed in human ADNFLE. V286L-TG rats displayed nicotine-induced abnormal motor activity including seizures in comparison to non-TGs. Response time following nicotine administration occurred faster in V286L-TG than in\nnon-TG rats. V286L-TG rats demonstrated spontaneous epileptic seizures, which are similar to human ADNFLE, and also showed a higher sensitivity to nicotine administration. Thus, the V286L-TG rat model could be a valuable tool for developing novel mechanism-driven treatment strategies for epilepsy and provide a better understanding of ADNFLE.","subitem_description_type":"Abstract"}]},"item_7_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"掲載誌：Neurosci Res 100,p.46-54,2015\n","subitem_description_type":"Other"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1901"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16027","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シバ, ユウコ"}]}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16028","nameIdentifierScheme":"WEKO"}],"names":[{"name":"柴, 祐子"}]}]},"item_7_radio_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"ETD"}]},"item_7_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Thesis"}]},"item_7_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neures.2015.06.003","subitem_relation_type_select":"DOI"}}]},"item_7_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.3","subitem_subject_scheme":"NDC"}]},"item_7_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shiba, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"16026","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1901_shiba_s1.pdf","filesize":[{"value":"218.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文要約","url":"https://hirosaki.repo.nii.ac.jp/record/4210/files/tdm_1901_shiba_s1.pdf"},"version_id":"f17335fe-bbb4-4bcf-9699-03729d9d9d33"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1901_shiba_a2.pdf","filesize":[{"value":"135.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4210/files/tdm_1901_shiba_a2.pdf"},"version_id":"31497a36-902c-49ac-aebd-1ee936092306"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1901_shiba_a1.pdf","filesize":[{"value":"196.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4210/files/tdm_1901_shiba_a1.pdf"},"version_id":"8cf98ac5-1978-4ecb-a947-77960e956320"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-20"}],"displaytype":"detail","filename":"tdm_1901_Shiba.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://hirosaki.repo.nii.ac.jp/record/4210/files/tdm_1901_Shiba.pdf"},"version_id":"70d82004-8d27-47f8-a602-e934c9dc4c45"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)","subitem_subject_scheme":"Other"},{"subitem_subject":"nicotinic acetylcholine　receptor (nAChR) mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"β2-subunit","subitem_subject_scheme":"Other"},{"subitem_subject":"epilepsy","subitem_subject_scheme":"Other"},{"subitem_subject":"seizures","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic rat","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor"}]},"item_type_id":"7","owner":"3","path":["673"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-27"},"publish_date":"2015-10-27","publish_status":"0","recid":"4210","relation_version_is_last":true,"title":["Spontaneous epileptic seizures in transgenic rats harboring a human ADNFLE missense mutation in the β2-subunit of the nicotinic acetylcholine receptor"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:34:38.478853+00:00"}