{"created":"2023-05-15T09:03:18.325958+00:00","id":4213,"links":{},"metadata":{"_buckets":{"deposit":"958cce23-98bd-4ca7-94c0-4280bc208acc"},"_deposit":{"created_by":3,"id":"4213","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4213"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004213","sets":["557:666:673"]},"author_link":["16037","16036","16035"],"item_7_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"内因性神経ペプチドSがラットにおける睡眠覚醒リズムに影響を与える"}]},"item_7_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ナイインセイ シンケイ ペプチド S ガ ラット ニオケル スイミン カクセイ リズム ニ エイキョウ オ アタエル"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"13","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-30"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neuropeptide S (NPS) is an endogenous peptide that exerts wakefulness promoting, analgesic, and anxiolytic effects when administered exogenously. However, it remains to be determined if endogenous NPS tone is involved in the control of the diurnal sleep–wake cycle, or spontanous behavior.In this study, we examined the effects of the NPS receptor antagonist [D-Cys(tBu)5]NPS (2 and 20 nmol, icv) on physiological sleep and spontaneous locomotor behavior. The higher dose of [D-Cys(tBu)5]NPS decreased the amount of time spent in wakefulness [control 782.5 ± 25.5 min, treatment 751.7 ± 28.1 min; p < 0.05] and increased the time spent in NREMS [control 572.6 ± 17.2 min, treatment 600.2 ± 26.1 min; p < 0.05]. There was no statistically significant difference in time spent in REMS. There were no behavioral changes including abnormal gross motor behavior in response to [D-Cys(tBu)5]NPS administration. Collectively these data suggest an involvement of the endogenous NPS/NPS receptor system in physiological sleep architecture.","subitem_description_type":"Abstract"}]},"item_7_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"掲載誌\nNeuroscience Letters, 381, 2014, P.94-97\ndoi:10.1016/j.neulet.2014.08.031","subitem_description_type":"Other"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1904"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16036","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオイシ, マサフミ"}]}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16037","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大石, 将文"}]}]},"item_7_radio_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"ETD"}]},"item_7_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Thesis"}]},"item_7_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.37","subitem_subject_scheme":"NDC"}]},"item_7_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Hospital, Hirosaki 036-8563,"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oishi, Masafumi"}],"nameIdentifiers":[{"nameIdentifier":"16035","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1904_oishi.pdf","filesize":[{"value":"235.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://hirosaki.repo.nii.ac.jp/record/4213/files/tdm_1904_oishi.pdf"},"version_id":"3f943533-36e4-49f9-9bdb-dd55674548bf"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1904_oishi_a2.pdf","filesize":[{"value":"133.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4213/files/tdm_1904_oishi_a2.pdf"},"version_id":"588dbfc2-c7bd-4929-835d-845ae67d7bf3"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1904_oishi_a1.pdf","filesize":[{"value":"248.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4213/files/tdm_1904_oishi_a1.pdf"},"version_id":"e343d121-8d8e-46a8-9008-7837a6c88978"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Endogenous neuropeptide S tone influences sleep–wake rhythm in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Endogenous neuropeptide S tone influences sleep–wake rhythm in rats"}]},"item_type_id":"7","owner":"3","path":["673"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-27"},"publish_date":"2015-10-27","publish_status":"0","recid":"4213","relation_version_is_last":true,"title":["Endogenous neuropeptide S tone influences sleep–wake rhythm in rats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:36:56.034988+00:00"}