{"created":"2023-05-15T09:03:18.429111+00:00","id":4215,"links":{},"metadata":{"_buckets":{"deposit":"48dcd474-febe-43f7-948e-875b7e37e108"},"_deposit":{"created_by":3,"id":"4215","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4215"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004215","sets":["557:666:673"]},"author_link":["16041","16042","16043"],"item_7_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"抗精神病薬投与中の高プロラクチン血症と凝固因子の関係"}]},"item_7_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウ セイシンビョウ ヤク トウヨ チュウ ノ コウ プロラクチン ケッショウ ト ギョウコ インシ ノ カンケイ"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"484","bibliographicPageStart":"477","bibliographicVolumeNumber":"2015","bibliographic_titles":[{"bibliographic_title":"Neuropsychiatric Disease and Treatment"}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-30"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The strong association between psychiatric patients who receive antipsychotics and the incidence of venous thromboembolism (VTE) is known. Although previous reports suggest that hyperprolactinemia often increases markers of activated coagulation, few studies have examined the direct relationship between the prolactin level elevated by antipsychotics and activated markers of activated coagulation. Method: The participants included 182 patients with schizophrenia (male =89, female =93) who received antipsychotic treatments for at least 3 months. Markers of VTE (D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin complex) and serum prolactin concentrations were measured. Results: Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002) and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026) but not of the thrombin–antithrombin complex level (r=0.117, ns) among men. However, no correlations were found between the VTE markers and prolactin levels among women. These results were confirmed using multiple regression analyses that included demographic factors and antipsychotic dosages. Conclusion: The current study indicates that hyperprolactinemia is associated with an increase in markers of activated coagulation among men receiving antipsychotics. This finding clinically implies that monitoring and modulating prolactin levels among men are important to decrease the risk of VTE.","subitem_description_type":"Abstract"}]},"item_7_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"掲載誌\nNeuropsychiatric Disease and Treatment, 11, 2015, p.477-484\nDOI http://dx.doi.org/10.2147/NDT.S75176","subitem_description_type":"Other"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1907"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16042","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシオカ, マサミチ"}]}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16043","nameIdentifierScheme":"WEKO"}],"names":[{"name":"石岡, 雅道"}]}]},"item_7_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dove Press Ltd"}]},"item_7_radio_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"ETD"}]},"item_7_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Thesis"}]},"item_7_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2147/NDT.S75176","subitem_relation_type_select":"DOI"}}]},"item_7_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.5","subitem_subject_scheme":"NDC"}]},"item_7_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishioka, Masamichi"}],"nameIdentifiers":[{"nameIdentifier":"16041","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1907_ishioka.pdf","filesize":[{"value":"414.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://hirosaki.repo.nii.ac.jp/record/4215/files/tdm_1907_ishioka.pdf"},"version_id":"57ec0abb-7b5d-449a-998f-fecaab03eb1c"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1907_ishioka_a2.pdf","filesize":[{"value":"143.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4215/files/tdm_1907_ishioka_a2.pdf"},"version_id":"0957acb0-48f5-4ed3-8bde-31ed81eed151"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1907_ishioka_a1.pdf","filesize":[{"value":"157.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4215/files/tdm_1907_ishioka_a1.pdf"},"version_id":"b0ff15e4-fd1e-40d7-9ca2-0913e90020dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"prolactin","subitem_subject_scheme":"Other"},{"subitem_subject":"antipsychotics","subitem_subject_scheme":"Other"},{"subitem_subject":"venous thromboembolism","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers"}]},"item_type_id":"7","owner":"3","path":["673"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-27"},"publish_date":"2015-10-27","publish_status":"0","recid":"4215","relation_version_is_last":true,"title":["Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:36:39.934982+00:00"}