{"created":"2023-05-15T09:03:18.494484+00:00","id":4216,"links":{},"metadata":{"_buckets":{"deposit":"e03f84bf-2f2f-41b3-930a-e8d89a9e060b"},"_deposit":{"created_by":3,"id":"4216","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4216"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004216","sets":["557:666:673"]},"author_link":["16046","16045","14591"],"item_7_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"糖尿病および認知症における血漿アミロイドβ４０および４０/４２比の上昇"}]},"item_7_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"トウニョウビョウ オヨビ ニンチショウ ニオケル ケッショウ アミロイドβ40 オヨビ 40/42 ヒノジョウショウ"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09-30","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"21","bibliographicPageStart":"1","bibliographic_titles":[{}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-30"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aim: The plasma Aß40/42 ratio is a possible biomarker for the onset of Alzheimer’s disease (AD). We here measured plasma Aß40 and Aß42 levels in patients with diabetes mellitus (DM) and dementia in order to clarify the relationship between DM\nand AD. Methods: Fifty-three patients, including 33 patients with DM and 25 patients with dementia, were assessed using the Mini-mental state examination (MMSE) and brain MRI, plasma Aß40 and Aß42, blood sugar levels, and HbA1c % were measured, and the genotype of apolipoprotein E was determined. Plasma Aß levels and blood sugar levels were measured in 16 out of 53 patients, following fasting and 2 hours after breakfast. Results: Plasma Aβ40 levels and the Aß40/42 ratio were increased in the DM with dementia group (p<0.01, p<0.001), while HbA1c % correlated with the Aß40/42 ratio in\nthe non-dementia group. MMSE scores were also associated with the plasma Aß40/42 ratio and Aß40 levels in the non-dementia group, independent of the presence of ApoEε4. We did not observed significant direct responses of plasma Aß protains to an increase in blood sugar levels. Conclusion: These results suggest that plasma Aß metabolism are closely related chronic hyperglycemia before the onset of dementia.","subitem_description_type":"Abstract"}]},"item_7_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"掲載誌\n弘前医学, 66(2-4), 2016, p.110-119","subitem_description_type":"Other"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲1905"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16045","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ウエノ, ヤエコ"}]}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16046","nameIdentifierScheme":"WEKO"}],"names":[{"name":"上野, 八重子"}]}]},"item_7_radio_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_radio_item":"ETD"}]},"item_7_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Thesis"}]},"item_7_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.32","subitem_subject_scheme":"NDC"}]},"item_7_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_7_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueno, Yaeko"}],"nameIdentifiers":[{"nameIdentifier":"14591","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1905_ueno.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://hirosaki.repo.nii.ac.jp/record/4216/files/tdm_1905_ueno.pdf"},"version_id":"ebb21507-ea71-41c0-903f-bd9588646d45"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1905_ueno_a2.pdf","filesize":[{"value":"123.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"審査要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4216/files/tdm_1905_ueno_a2.pdf"},"version_id":"60e2d233-c2d5-4ee9-99ab-036aa0b4e058"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"tdm_1905_ueno_a1.pdf","filesize":[{"value":"184.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"内容要旨","url":"https://hirosaki.repo.nii.ac.jp/record/4216/files/tdm_1905_ueno_a1.pdf"},"version_id":"a8ab1c76-12f3-447a-9f58-0b259414ca9f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dementia","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetes mellitus","subitem_subject_scheme":"Other"},{"subitem_subject":"HbA1c","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasma Aß40","subitem_subject_scheme":"Other"},{"subitem_subject":"Plasma Aß40/42ratio","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Increases in plasma Aß40 levels and the Aß40/42 ratio in patients with Diabetes Mellitus and dementia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Increases in plasma Aß40 levels and the Aß40/42 ratio in patients with Diabetes Mellitus and dementia"}]},"item_type_id":"7","owner":"3","path":["673"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-27"},"publish_date":"2015-10-27","publish_status":"0","recid":"4216","relation_version_is_last":true,"title":["Increases in plasma Aß40 levels and the Aß40/42 ratio in patients with Diabetes Mellitus and dementia"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:49:59.849769+00:00"}