{"created":"2023-05-15T09:03:22.562169+00:00","id":4305,"links":{},"metadata":{"_buckets":{"deposit":"a956fc0f-35cf-4cb6-b60a-cf147915ee2d"},"_deposit":{"created_by":3,"id":"4305","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4305"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00004305","sets":["557:677:681"]},"author_link":["16304","16302","16303"],"item_7_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"アルツハイマー型認知症における局所脳血流とMini-Mental State Examination Scoreの関連性"}]},"item_7_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"Association between regional cerebral blood flow and Mini-Mental State Examination score in patients with Alzheimer's disease"}]},"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-23","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_7_date_granted_66":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-23"}]},"item_7_degree_grantor_64":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"弘前大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"11101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_63":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（保健学）"}]},"item_7_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー病患者の脳血流は早期段階から減少している。現在、アルツハイマー病の脳血流は、統計解析を用いたZ-scoreで評価されている。しかしながら、Z-scoreは、脳血流の障害領域を考慮していない。本研究では、脳表面領域とZ-scoreを考慮したΣzSを定義し、アルツハイマー病患者の認知障害の重症度示すミニメンタルステート検査を使用して測定した局所脳血流との関連性を調べた。本研究において、後部帯状回のΣzSとミニメンタルステート検査の下位項目1、2、5で負の相関が認められた。さらに、ミニメンタルステート検査の合計スコアと脳の細分化された領域のブロードマン領野30で負の相関が認められた。本研究の結果は、局所脳血流代謝の指標として有用であり、アルツハイマー病患者の認知機能の解釈を深めることができるかもしれない。","subitem_description_type":"Abstract"}]},"item_7_dissertation_number_67":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲065"}]},"item_7_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16303","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サイトウ, 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