{"created":"2023-05-15T09:04:14.309960+00:00","id":5290,"links":{},"metadata":{"_buckets":{"deposit":"51c7e0b0-ff62-4ec5-bb47-11245c9fa5ce"},"_deposit":{"created_by":11,"id":"5290","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"5290"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00005290","sets":["557:561:936"]},"author_link":["9620","11941","19267","9624","9629","11939"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"103","bibliographicPageStart":"91","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"母親の松果体が仔の胎生発達に及ぼす影響について，著者ら自身の研究結果との関連を中心に概説した．次の項目につき記述，解説した：1．研究の糸口をなす基礎的実験データの集積から母親の松果体除去による胚発生異常の発見に至る経緯，続いて松果体ホルモンのセロトニンとメラトニンについてそれらの体内分布，個体発生や系統発生との関係など．2．発生異常に関与するBrachyury 遺伝子，および発生・分化，ネズミおよび正常ヒトと腫瘍患者での発現とその遺伝子を治療標的とする研究との関連．3．松果体と血糖調節機序または糖尿病との関連：1）血糖調節機序と妊娠との関連：血糖調節ホルモンおよびプロラクチンと末梢性セロトニンについて．2）糖尿病による胎生発達異常と母親の松果体除去誘発性胎生発達異常との関連：（1）母親の糖尿病と胎生発達異常；（2）免疫機能活性化による発達異常の減少．\nWe surveyed the references relevant to the effects of mother’s pineal gland on the prenatal development of pups, including our own results. Following items were described and interpreted: 1. Details of events from the accumulation of basic experimental data making clues to discovery of developmental abnormality in pups induced by mother’s pinealectomy, and the distribution and relationships to ontogeny and phylogeny of the pineal hormones, i.e. serotonin and melatonin. 2. The Brachyury gene, which is involved in the developmental abnormality, and its relationships with the development or differentiation, the expression in murine and normal man and tumor patients, and researches in which the gene was used as the target of tumor therapy. 3. Pineal relationships to blood glucose regulatory mechanisms or diabetes mellitus: 1） The relationships between blood glucose regulatory mechanisms and pregnancy: On regulatory hormones of the blood glucose level,　especially on prolactin and the peripheral serotonin. 2） The relationship between the developmental abnormality due to diabetes mellitus and that induced by maternal pinealectomy: （1） mother’s diabetes mellitus and developmental abnormality; （2） reduction of developmental abnormality by the activation of immune functions. 3） blood glucose regulatory hormones and endocrine organs influenced by pinealectomy.","subitem_description_type":"Abstract"}]},"item_10001_full_name_25":{"attribute_name":"氏名（ヨミ）","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9620","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カチ, タカシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11941","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カチ, ヒトミ"}]}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"40021529669","subitem_relation_type_select":"NAID"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_10001_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_10001_text_23":{"attribute_name":"タイトル(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ショウカタイ　ト　タイセイ　ハッタツ　Brachyury　イデンシ　ケットウ　チョウセツ　キジョ　トノ　カンレン　ケイタイ　セイリガク　カラ　ビョウリガク　マデ"}]},"item_10001_text_24":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"青森県弘前市樹木4-1-21"},{"subitem_text_value":"東北女子大学家政学部健康栄養学科"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加地, 隆"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加地, 眸"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kachi, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kachi, Hitomi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-11"}],"displaytype":"detail","filename":"HirosakiMedJ_68(2-4)_91.pdf","filesize":[{"value":"634.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_68(2-4)_91.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/5290/files/HirosakiMedJ_68(2-4)_91.pdf"},"version_id":"eaac693e-0c8e-420e-a887-6502849f0629"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"セロトニン","subitem_subject_scheme":"Other"},{"subitem_subject":"メラトニン","subitem_subject_scheme":"Other"},{"subitem_subject":"原腸形成","subitem_subject_scheme":"Other"},{"subitem_subject":"系統発生","subitem_subject_scheme":"Other"},{"subitem_subject":"/プロラクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"serotonin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"melatonin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gastrulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phylogeny","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prolactin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"松果体と胎生発達,Brachyury遺伝子,血糖調節機序との関連 : 形態生理学から病理学まで","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"松果体と胎生発達,Brachyury遺伝子,血糖調節機序との関連 : 形態生理学から病理学まで"},{"subitem_title":"PINEAL RELATIONSHIPS TO EMBRYONAL DEVELOPMENT, BRACHYURY GENE AND BLOOD GLUCOSE REGULATORY MECHANISMS FROM MORPHOLOPHYSIOLOGY TO PATHOLOGY","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"11","path":["936"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-11"},"publish_date":"2018-06-11","publish_status":"0","recid":"5290","relation_version_is_last":true,"title":["松果体と胎生発達,Brachyury遺伝子,血糖調節機序との関連 : 形態生理学から病理学まで"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T11:09:09.422027+00:00"}