{"created":"2023-05-15T09:04:21.823005+00:00","id":5434,"links":{},"metadata":{"_buckets":{"deposit":"c7432e28-2c4d-451c-8e99-563d9cdd8cb0"},"_deposit":{"created_by":11,"id":"5434","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"5434"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00005434","sets":["375:376:377"]},"author_link":["14291","7528","19628","11459","11871","13802","16021","11697","11458"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"950","bibliographicPageStart":"942","bibliographicVolumeNumber":"42","bibliographic_titles":[{},{"bibliographic_title":"Kidney & blood pressure research","bibliographic_titleLang":"en"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cylindromatosis (CYLD), a deubiquitinase, negatively regulates nuclear factor-κB in various cells. However, its potential roles in glomerular inflammation remain unclear. Because the activation of the Toll-like receptor 3 (TLR3)/type I interferon (IFN) pathways plays a pivotal role in chronic kidney diseases (CKD), we examined the role of CYLD in the TLR3 signaling in cultured human mesangial cells (MCs).","subitem_description_type":"Abstract"},{"subitem_description":"We stimulated CYLD-silenced MCs with polyinosinic-polycytidylic acid (poly IC), a synthetic analogue of dsRNA, and studied representative TLR3/IFN-β pathways (i.e., TLR3/IFN-β/retinoic acid-inducible gene-I (RIG-I)/CCL5, and TLR3/IFN-β/melanoma differentiation associated gene 5 (MDA5)/CXCL10 axes) using RT-PCR, western blotting, and ELISA. We also used immunofluorescence staining and microscopy to examine mesangial CYLD expression in biopsied specimens from patients with CKD.","subitem_description_type":"Abstract"},{"subitem_description":"CYLD silencing resulted in an increase of poly IC-induced RIG-I and MDA5 protein levels and increased CCL5 and CXCL10 mRNA and protein expression, but unexpectedly decreased mRNA expressions of RIG-I and MDA5. Interestingly, CYLD silencing did not affect IFN-β or the phosphorylated STAT1 (signal transducers and activator of transcription protein 1). CYLD was highly expressed in biopsied specimens from patients with proliferative lupus nephritis (LN).","subitem_description_type":"Abstract"},{"subitem_description":"CYLD inhibits post-transcriptional regulation of RIG-I and MDA5 expression following TLR3 activation in MCs. CYLD may be involved in the pathogenesis of CKD, especially pathogenesis of LN.","subitem_description_type":"Abstract"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_relation_12":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"29166644","subitem_relation_type_select":"PMID"}}]},"item_3_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1159/000485084","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11085044","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1423-0143","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaizumi, Tadaatsu"}],"nameIdentifiers":[{"nameIdentifier":"11458","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"318","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/318_ja.html"}]},{"creatorNames":[{"creatorName":"Hayakari, Ryo"}],"nameIdentifiers":[{"nameIdentifier":"14291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Shojiro"}],"nameIdentifiers":[{"nameIdentifier":"19628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Tomomi"}],"nameIdentifiers":[{"nameIdentifier":"13802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumiya, Tomoh"}],"nameIdentifiers":[{"nameIdentifier":"11871","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"319","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/319_ja.html"}]},{"creatorNames":[{"creatorName":"Yoshida, Hidemi"}],"nameIdentifiers":[{"nameIdentifier":"11459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuruga, Kazushi"}],"nameIdentifiers":[{"nameIdentifier":"16021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawaguchi, Shogo"}],"nameIdentifiers":[{"nameIdentifier":"11697","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"200000550","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/200000550_ja.html"}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"7528","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-22"}],"displaytype":"detail","filename":"485084_1.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"485084_1.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/5434/files/485084_1.pdf"},"version_id":"ef117c40-65eb-4eac-99e2-0f2ad4192e67"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cells, Cultured","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DEAD Box Protein 58","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Deubiquitinating Enzyme CYLD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon-Induced Helicase, IFIH1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lupus Nephritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mesangial Cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Renal Insufficiency, Chronic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Signal Transduction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Toll-Like Receptor 3","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells."}]},"item_type_id":"3","owner":"11","path":["377"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-02-22"},"publish_date":"2019-02-22","publish_status":"0","recid":"5434","relation_version_is_last":true,"title":["Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells."],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T10:40:22.309173+00:00"}