{"created":"2023-05-15T09:04:22.797010+00:00","id":5457,"links":{},"metadata":{"_buckets":{"deposit":"ec99bfce-a64c-4f11-93d3-32b06b2c0a28"},"_deposit":{"created_by":11,"id":"5457","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"5457"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00005457","sets":["557:558:559"]},"author_link":["14629","19719","19718","19720","19717","19724","19716","19721","19726","16420","19723","19725","19722"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-10-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"13708","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"SCIENTIFIC REPORTS"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"One of the major challenges in cell-based cardiac regenerative medicine is the in vitro construction of three-dimensional (3D) tissues consisting of induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) and a blood vascular network supplying nutrients and oxygen throughout the tissue after implantation. We have successfully built a vascularized iPSC-CM 3D-tissue using our validated cell manipulation technique. In order to evaluate an availability of the 3D-tissue as a biomaterial, functional morphology of the tissues was examined by light and transmission electron microscopy through their implantation into the rat infarcted heart. Before implantation, the tissues showed distinctive myofibrils within iPSC-CMs and capillary-like endothelial tubes, but their profiles were still like immature. In contrast, engraftment of the tissues to the rat heart led the iPSC-CMs and endothelial tubes into organization of cell organelles and junctional apparatuses and prompt development of capillary network harboring host blood supply, respectively. A number of capillaries in the implanted tissues were derived from host vascular bed, whereas the others were likely to be composed by fusion of host and implanted endothelial cells. Thus, our vascularized iPSC-CM 3D-tissues may be a useful regenerative paradigm which will require additional expanded and long-term studies.","subitem_description_type":"Abstract"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-017-14053-0","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Hirosaki Univ, Dept Anat Sci, Grad Sch Med"},{"subitem_text_value":"Osaka Univ, Dept Frontier Biosci, Grad Sch Frontier Biosci"},{"subitem_text_value":"Osaka Univ, Dept Cardiovasc Surg, Grad Sch Med"},{"subitem_text_value":"Osaka Univ, Dept Cardiovasc Surg, Grad Sch Med"},{"subitem_text_value":"Osaka Univ, Dept Frontier Biosci, Grad Sch Frontier Biosci"},{"subitem_text_value":"Osaka Univ, Dept Frontier Biosci, Grad Sch Frontier Biosci"},{"subitem_text_value":"Osaka Univ, Dept Frontier Biosci, Grad Sch Frontier Biosci"},{"subitem_text_value":"Kyowa Hakko Bio Co LTD"},{"subitem_text_value":"Hirosaki Univ, Dept Anat Sci, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Anat Sci, Grad Sch Med"},{"subitem_text_value":"Osaka Univ, Dept Cardiovasc Surg, Grad Sch Med"},{"subitem_text_value":"Osaka Univ, Dept Frontier Biosci, Grad Sch Frontier Biosci"},{"subitem_text_value":"Hirosaki Univ, Dept Anat Sci, Grad Sch Med"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Narita, Hirokazu"}],"nameIdentifiers":[{"nameIdentifier":"19716","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shima, Fumiaki"}],"nameIdentifiers":[{"nameIdentifier":"19717","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoyama, Junya"}],"nameIdentifiers":[{"nameIdentifier":"19718","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyagawa, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"19719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukamoto, Yoshinari"}],"nameIdentifiers":[{"nameIdentifier":"19720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamura, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"19721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiura, Ayami"}],"nameIdentifiers":[{"nameIdentifier":"19722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumoto, Ken"}],"nameIdentifiers":[{"nameIdentifier":"19723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chiba, Tomohiro"}],"nameIdentifiers":[{"nameIdentifier":"14629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"16420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sawa, Yoshiki"}],"nameIdentifiers":[{"nameIdentifier":"19724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akashi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"19725","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimoda, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"19726","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-07"}],"displaytype":"detail","filename":"s41598-017-14053-0.pdf","filesize":[{"value":"3.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"s41598-017-14053-0","url":"https://hirosaki.repo.nii.ac.jp/record/5457/files/s41598-017-14053-0.pdf"},"version_id":"d40993a4-6462-4b05-b254-7e5c8273b012"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Engraftment and morphological development of vascularized human iPS cell-derived 3D-cardiomyocyte tissue after xenotransplantation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Engraftment and morphological development of vascularized human iPS cell-derived 3D-cardiomyocyte tissue after xenotransplantation"}]},"item_type_id":"3","owner":"11","path":["559"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-07"},"publish_date":"2019-03-07","publish_status":"0","recid":"5457","relation_version_is_last":true,"title":["Engraftment and morphological development of vascularized human iPS cell-derived 3D-cardiomyocyte tissue after xenotransplantation"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T09:50:49.162326+00:00"}