{"created":"2023-05-15T09:04:24.284535+00:00","id":5480,"links":{},"metadata":{"_buckets":{"deposit":"328feb81-d21a-4984-a6c7-f9403490e183"},"_deposit":{"created_by":11,"id":"5480","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"5480"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00005480","sets":["953:954:955"]},"author_link":["13944","19763","13943","15954","13951","15958","13980","11600","11606","19762","11610","19774","11604","19768","15942","11890","19767"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"60","bibliographicPageEnd":"101508","bibliographicPageStart":"101500","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"ONCOTARGET"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The clinical impact of neoadjuvant chemotherapy (NAC) on oncological outcomes in patients with locally advanced upper tract urothelial carcinoma (UTUC) remains unclear. We investigated the oncological outcomes of platinum-based NAC for locally advanced UTUC. \n\nResults: Of 234 patients, 101 received NAC (NAC group) and 133 did not (Control [Ctrl] group). The regimens in the NAC group included gemcitabine and carboplatin (75%), and gemcitabine and cisplatin (21%). Pathological downstagings of the primary tumor and lymphovascular invasion were significantly improved in the NAC than in the Ctrl groups. NAC for locally advanced UTUC significantly prolonged recurrence-free and cancer-specific survival. Multivariate Cox regression analysis using an inverse probability of treatment weighted (IPTW) method showed that NAC was selected as an independent predictor for prolonged recurrence-free and cancer-specific survival. However, the influence of NAC on overall survival was not statistically significant. \n\nMaterials and Methods: A total of 426 patients who underwent radical nephroureterectomy at five medical centers between January 1995 and April 2017 were examined retrospectively. Of the 426 patients, 234 were treated for a highrisk disease (stages cT3-4 or locally advanced [cN+] disease) with or without NAC. NAC regimens were selected based on eligibility of cisplatin. We retrospectively evaluated post-therapy pathological downstaging, lymphovascular invasion, and prognosis stratified by NAC use. Multivariate Cox regression analysis was performed for independent factors for prognosis. \n\nConclusions: Platinum-based NAC for locally advanced UTUC potentially improves oncological outcomes. Further prospective studies are needed to clarify the clinical benefit of NAC for locally advanced UTUC.","subitem_description_type":"Abstract"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_relation_13":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.18632/oncotarget.21551","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1949-2553","subitem_source_identifier_type":"ISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Tohoku Med & Pharmaceut Univ, Dept Urol"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Adv Transplant & Regenerat Med, Grad Sch Med"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"},{"subitem_text_value":"Aomori Rosai Hosp, Dept Urol, Hachinohe"},{"subitem_text_value":"Mutsu Gen Hosp, Dept Urol"},{"subitem_text_value":"Tsugaru Gen Hosp, Dept Urol"},{"subitem_text_value":"Aomori Prefectural Cent Hosp, Dept Urol"},{"subitem_text_value":"Hirosaki Univ, Dept Urol, Grad Sch Med"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kubota, Yuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatakeyama, Shingo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tanaka, Toshikazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwamura, Hiromichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mikami, Jotaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Hayato"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tobisawa, Yuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoneyama, Tohru"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoneyama, Takahiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashimoto, Yasuhiro"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Koie, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshikawa, Kazuaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawaguchi, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohyama, Chikara"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-03-08"}],"displaytype":"detail","filename":"oncotarget-101500.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"oncotarget-101500","url":"https://hirosaki.repo.nii.ac.jp/record/5480/files/oncotarget-101500.pdf"},"version_id":"8161bfe9-87fc-4a70-997d-c56ebd3a3a9c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Oncological outcomes of neoadjuvant chemotherapy in patients with locally advanced upper tract urothelial carcinoma: a multicenter study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Oncological outcomes of neoadjuvant chemotherapy in patients with locally advanced upper tract urothelial carcinoma: a multicenter study"}]},"item_type_id":"3","owner":"11","path":["955"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-03-08"},"publish_date":"2019-03-08","publish_status":"0","recid":"5480","relation_version_is_last":true,"title":["Oncological outcomes of neoadjuvant chemotherapy in patients with locally advanced upper tract urothelial carcinoma: a multicenter study"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T10:00:37.250394+00:00"}