@article{oai:hirosaki.repo.nii.ac.jp:00005523,
 author = {Tanaka, Nahoko and Hiraga, Hiroto and Sakuraba, Hirotake and Murai, Yasuhisa and Maeda, Takato and Watanabe, Rina and Ota, Shinji and Akemoto, Yui and Hasui, Keisuke and Yoshida, Shukuko and Asano, Krisana and Nakane, Akio and Fukuda, Shinsaku},
 issue = {1-4},
 journal = {弘前医学},
 month = {Mar},
 note = {Vitamin A is essential for maintenance of homeostasis, and it also regulates various immune mechanisms.Listeria monocytogenes is a gram-positive bacillus that invades the cytoplasm of phagocytes and performs intracellular multiplication, and is often used as a tool for functional analysis of macrophages. In this study, we investigated the changes of macrophages under vitamin A deficiency（ VAD） using L. monocytogenes. During L. monocytogenes infection,apoptosis was increased in CD11b-positive splenocytes of VAD mice compared with vitamin A sufficient （VAS）mice. A similar result was obtained with peritoneal exudate cells （PECs）. Significant increase of apoptosis due to the administration of Ro41-5253, an inhibitor of retinoic acid receptor, was also observed in the macrophage cell line RAW264.7. Furthermore, in VAD mice, the number of bacteria in the spleens and livers was significantly increased.These results suggest that excessive apoptosis of macrophages occurs under VAD condition, leading to impaired host resistance to L. monocytogenes. Taken together, vitamin A contributes to the maintenance of homeostasis by regulating macrophage functions, indicating the importance of vitamin A supplementation.},
 pages = {163--171},
 title = {Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages},
 volume = {69},
 year = {2019}
}