{"created":"2023-05-15T09:04:27.070584+00:00","id":5523,"links":{},"metadata":{"_buckets":{"deposit":"6b584c59-6d60-4cfd-815e-904076269805"},"_deposit":{"created_by":11,"id":"5523","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"5523"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00005523","sets":["557:561:958"]},"author_link":["14785","11701","11512","19865","19870","19866","9436","11509","19868","13572","19869","11191","19867"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"171","bibliographicPageStart":"163","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Vitamin A is essential for maintenance of homeostasis, and it also regulates various immune mechanisms.Listeria monocytogenes is a gram-positive bacillus that invades the cytoplasm of phagocytes and performs intracellular multiplication, and is often used as a tool for functional analysis of macrophages. In this study, we investigated the changes of macrophages under vitamin A deficiency（ VAD） using L. monocytogenes. During L. monocytogenes infection,apoptosis was increased in CD11b-positive splenocytes of VAD mice compared with vitamin A sufficient （VAS）mice. A similar result was obtained with peritoneal exudate cells （PECs）. Significant increase of apoptosis due to the administration of Ro41-5253, an inhibitor of retinoic acid receptor, was also observed in the macrophage cell line RAW264.7. Furthermore, in VAD mice, the number of bacteria in the spleens and livers was significantly increased.These results suggest that excessive apoptosis of macrophages occurs under VAD condition, leading to impaired host resistance to L. monocytogenes. Taken together, vitamin A contributes to the maintenance of homeostasis by regulating macrophage functions, indicating the importance of vitamin A supplementation.","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pathology and Laboratory Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Shibata Irika Co"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Nahoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiraga, Hiroto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sakuraba, Hirotake"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Murai, Yasuhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maeda, Takato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Rina"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akemoto, Yui"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hasui, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Shukuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asano, Krisana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Shinsaku"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-10"}],"displaytype":"detail","filename":"HirosakiMedJ_69(1-4)_163.pdf","filesize":[{"value":"902.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_69(1-4)_163.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/5523/files/HirosakiMedJ_69(1-4)_163.pdf"},"version_id":"382fc5a7-ef84-44d4-bab6-37ff6bcedd69"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Vitamin A","subitem_subject_scheme":"Other"},{"subitem_subject":"Vitamin A deficiency","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"Listeria monocytogenes","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages"}]},"item_type_id":"3","owner":"11","path":["958"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-04-10"},"publish_date":"2019-04-10","publish_status":"0","recid":"5523","relation_version_is_last":true,"title":["Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T09:58:59.000336+00:00"}