{"created":"2023-05-15T09:04:45.419657+00:00","id":5897,"links":{},"metadata":{"_buckets":{"deposit":"2aee4b8b-80cf-4e91-9e67-19a94e2a05a1"},"_deposit":{"created_by":11,"id":"5897","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"5897"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00005897","sets":["557:561:981"]},"author_link":["20455","20453","20454","11980","11977","11976","21268","20457","12011","19858"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"155","bibliographicPageStart":"148","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Coronary spastic angina （CSA） has become increasingly important for clinical practice. β-arrestin regulates a large network of cellular responses including inflammation and muscle contraction. However, little is known about its role in the pathogenesis of CSA. In this study, we performed mutational analysis of β-arrestin1 and β-arrestin2 genes in CSA patients. The study population included 20 CSA patients and 5 control subjects. Mutational analyses of the coding egions of β-arrestins were performed by direct sequencing. In β-arrestin1, single base heterozygous substitution at nucleotide position 176 in exon 5 was detected in 2 of 20 CSA patients, whereas no substitution was detected in control subjects. We subsequently performed an association study involving 50 CSA patients and 50 control subjects. No ifference was found in the incidence of the mutation between the two groups （p=0.44）. In β-arrestin2, single base substitution at nucleotide position 61 in exon 11 was detected. This substitution was homozygous in 13 and heterozygous in 7 of 20 CSA patients, whereas all homozygous in 5 control subjects. These substitutions were well-annotated SNPs rs877711 and rs1045280, respectively） and did not cause amino acid replacement. No significant substitution of the  oding regions of β-arrestins was detected in Japanese CSA patients.","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Stroke and Cerebrovascular Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Health Promotion, Hirosaki University Graduate School of Health Sciences"},{"subitem_text_value":"Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kudo, Natsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kawamura, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakata, Masamichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nozaka, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitayama, Kazutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miura, Naotake"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Makoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Hirofumi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-06"}],"displaytype":"detail","filename":"Hirosaki Med J 70-2-4_148.pdf","filesize":[{"value":"939.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Hirosaki Med J 70-2-4_148","url":"https://hirosaki.repo.nii.ac.jp/record/5897/files/Hirosaki Med J 70-2-4_148.pdf"},"version_id":"3a829bd0-d575-494c-aa45-8d19ee36911e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Coronary spastic angina","subitem_subject_scheme":"Other"},{"subitem_subject":"Prinzmetal variant angina","subitem_subject_scheme":"Other"},{"subitem_subject":"β-arrestin","subitem_subject_scheme":"Other"},{"subitem_subject":"Mutational analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"Direct sequencing","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina"}]},"item_type_id":"3","owner":"11","path":["981"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-06"},"publish_date":"2020-03-06","publish_status":"0","recid":"5897","relation_version_is_last":true,"title":["Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T09:42:39.149496+00:00"}