{"created":"2023-05-15T09:04:45.480935+00:00","id":5898,"links":{},"metadata":{"_buckets":{"deposit":"9f9eecee-9ccf-4d9d-bd28-c1f257423025"},"_deposit":{"created_by":11,"id":"5898","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"5898"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00005898","sets":["557:561:981"]},"author_link":["14792","20458","11861"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"162","bibliographicPageStart":"156","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" In kidney transplantation, stable hemodynamics is essential to preserve graft function. We used ketamine as an anesthetic because of its sympathomimetic properties. On the other hand, ketamine has several adverse effects, such as prolonged emergence from anesthesia or psychological reactions. Altered ketamine pharmacokinetics was previously reported in rabbits with renal nsufficiency, but no study has examined human living kidney transplantation, which has the potential to cause renal nsufficiency in the donor and recipient. Therefore, we evaluated ketamine pharmacokinetics in the donor and recipient of living kidney transplantation in various situation including ABO blood type-compatible and -incompatible transplantation.\nMaterials and Methods: We examined the ketamine pharmacokinetics in donors （n=8）, and ABO blood type -compatible （n=8） and -incompatible （n=8） recipients of living kidney transplantation. We also measured the estimated glomerular filtration ratio（ eGFR）, blood urea nitrogen（ BUN）, and serum creatinine in these patients.\nResults: The time course of changes in the ketamine level after stopping ketamine administration did not differ between the donors and recipients. We also found that the eGFR in recipients gradually improved 48 h after the kidney transplantation. No patient developed ketamine-related adverse effects or allograft rejection.\nConclusion: We conclude that ketamine can be safely applied as an adjuvant with intravenous anesthesia during ABO blood type-compatible and -incompatible living kidney transplantation.","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Hospital"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Anna"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kushikata, Tetsuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hirota, Kazuyoshi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-06"}],"displaytype":"detail","filename":"Hirosaki Med J 70-2-4_156.pdf","filesize":[{"value":"776.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Hirosaki Med J 70-2-4_156","url":"https://hirosaki.repo.nii.ac.jp/record/5898/files/Hirosaki Med J 70-2-4_156.pdf"},"version_id":"4e7cbaac-20e8-4c0b-b1e4-a411a9aeebb6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ketamine","subitem_subject_scheme":"Other"},{"subitem_subject":"Living kidney transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"ABO blood type-compatible and -incompatible kidney transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"Pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"Graft function","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ketamine pharmacokinetics in recipients and donors of ABO blood type-compatible and -incompatible living kidney transplantation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ketamine pharmacokinetics in recipients and donors of ABO blood type-compatible and -incompatible living kidney transplantation"}]},"item_type_id":"3","owner":"11","path":["981"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-06"},"publish_date":"2020-03-06","publish_status":"0","recid":"5898","relation_version_is_last":true,"title":["Ketamine pharmacokinetics in recipients and donors of ABO blood type-compatible and -incompatible living kidney transplantation"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T11:53:09.938817+00:00"}