{"created":"2023-05-15T09:05:27.036469+00:00","id":6732,"links":{},"metadata":{"_buckets":{"deposit":"38d806fe-35eb-4d40-b236-dd744481f4ff"},"_deposit":{"created_by":11,"id":"6732","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"6732"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00006732","sets":["557:561:1053"]},"author_link":["11859","13089","21733","21734","11861"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-4","bibliographicPageEnd":"14","bibliographicPageStart":"6","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Initial distribution volume of glucose （IDVG） has been demonstrated to reflect central extracellular fluid （ECF）volume and can be used as an indicator of cardiac preload. However, it is unknown whether IDVG reflects the cardiacpreload in septic patients. This study aimed to investigate the changes in IDVG in endotoxin（ ET）-induced septic pigmodels.\nMETHODS: We anesthetized 13pigs and sepsis was induced with intravenous ET. Five pigs were used to investigatechanges in IDVG, 3pigs were used as controls and 5pigs underwent fluid resuscitation with Ringer’s lactate solutionsafter ET. IDVG was measured with 2g glucose and calculated with one compartment model. IDVG, CO, intrathoracicblood volume （ITBV）, and other parameters were measured after ET. The statistical analysis was performed withRM-ANOVA, followed by Dunnett’s test or the Newman-Keuls test. P<0.05 was considered significant.\nRESULTS: CO and systolic BP significantly decreased and lactate levels significantly increased 4h after ET. IDVGand ITBV significantly decreased but central venous pressure did not change 4h after ET. IDVG and CO weresignificantly increased with volume loading, but the effects disappeared after 1h.\nCONCLUSIONS: IDVG reflected the changes in the central ECF volumes and can be an indicator of cardiac preload\nin septic states.","subitem_description_type":"Abstract"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Anesthesiology, Hirosaki university Graduate School of Medicine"},{"subitem_text_value":"Division of Intensive Care, Hirosaki University Hospital, Hirosaki"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki university Graduate School of Medicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki university Graduate School of Medicine"},{"subitem_text_value":"Department of Anesthesiology, Hirosaki university Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suganuma, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"21733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashiba, Eiji"}],"nameIdentifiers":[{"nameIdentifier":"11859","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"509","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/509_ja.html"}]},{"creatorNames":[{"creatorName":"Akaishi, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"21734","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"200000256","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/200000256_ja.html"}]},{"creatorNames":[{"creatorName":"Saito, Junichi"}],"nameIdentifiers":[{"nameIdentifier":"13089","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000841","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000841_ja.html"}]},{"creatorNames":[{"creatorName":"Hirota, Kazuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"11861","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"293","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/293_ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","displaytype":"detail","filename":"Hirosaki Med J 72-1-4_6.pdf","filesize":[{"value":"327.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"url":"https://hirosaki.repo.nii.ac.jp/record/6732/files/Hirosaki Med J 72-1-4_6.pdf"},"version_id":"6e9bf07d-ae02-4e91-9b23-15bea5dea6d6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Initial distribution volume of glucose","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiac preload","subitem_subject_scheme":"Other"},{"subitem_subject":"fluid volume monitoring","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Changes in the Initial Distribution Volume of Glucose in Endotoxin-induced Septic Pig Models","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes in the Initial Distribution Volume of Glucose in Endotoxin-induced Septic Pig Models"}]},"item_type_id":"3","owner":"11","path":["1053"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-22"},"publish_date":"2022-04-22","publish_status":"0","recid":"6732","relation_version_is_last":true,"title":["Changes in the Initial Distribution Volume of Glucose in Endotoxin-induced Septic Pig Models"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2023-05-15T11:33:02.569733+00:00"}