@article{oai:hirosaki.repo.nii.ac.jp:00006743,
 author = {Annells, Azusa and Futagami, Masayuki and Osawa, Yuki and Oishi, Maika and Washima, Haruka and Sugimoto, Rina and Tsushima, Ryuto and Takenoko, Kenichi and Kurotaki, Saki and Taguchi, Tomoko and Maeda, Jyuria and Kadonosawa, Yuka and Ebina, Anna and Akaishi, Asami and Miura, Rie and Matsumura, Yukiko and Yokoyama, Yoshihito},
 issue = {1-4},
 journal = {弘前医学},
 month = {Mar},
 note = {ackground: Women often experience medically unexplained symptoms as they age, and their possible causesinclude changes in autonomic activity. Heart rate variability is a relevant marker for autonomic function.
Methods: The autonomic activities of patients who underwent gynecologic surgery were prospectively measured andevaluated by menopausal status. Parameters included the standard deviation of the mean R-to-R intervals （SDNN）and index of the sympathetic nervous system（ SNS） function. Patients also evaluated the severity of their headache,hot flashes, anxiety, irritability, fatigue and shoulder stiffness using the visual analog scale （VAS-P, VAS-H, VAS-A,VAS-I, VAS-F and VAS-S, respectively）. Measurements were conducted shortly before, immediately after, and 1week after surgery.
Results: The study cohort （N = 101） consisted of 14 premenopausal, 39 surgically menopausal, and 48 naturallymenopausal patients. At 1 week after surgery, surgically menopausal patients had significantly smaller mean SDNNthan premenopausal patients. Surgically menopausal patients also showed significant correlation between the SNSindex and VAS-I and VAS-F.
Conclusions: The SNS index in surgically menopausal patients can be a promising tool for evaluating the severityof menopausal symptoms. Parasympathetic nerve activity decreased immediately after the operation in the surgicalmenopausal group. Therefore, early hormone replacement therapy may be necessary in surgical menopause group.},
 pages = {51--61},
 title = {Perioperative heart rate variability analysis to evaluate autonomic activity in gynecologic patients},
 volume = {72},
 year = {2022}
}