@article{oai:hirosaki.repo.nii.ac.jp:00007181,
 author = {Saito, Kensuke and Yoshizawa, Tadashi and Morohashi, Satoko and Seino, Hiroko and Goto, Shintaro and Muroya, Takahiro and Yokoyama, Hiroshi and Yoshida, Eri and Miura, Hiroyuki and Yu, Chen and Kijima, Hiroshi and Kakeda, Shingo and Hakamada, Kenichi and Sato, Atsushi},
 issue = {1-4},
 journal = {弘前医学, Hirosaki Medical Journal},
 month = {Mar},
 note = {Background: Positron emission tomography（PET） is the standard method for metabolic and quantitative evaluation of therapeutic response to chemotherapy in solid tumors. This study determined the ability of PET parameters used in combination in predicting recurrence-free survival（RFS）after neoadjuvant chemotherapy （NAC）and operation for esophageal cancer.
Methods: This single-center retrospective study included 96 patients who underwent 18F-fluorodeoxyglucose-PET/computed tomography before and after NAC. Maximum standardised uptake value（SUVmax）after NAC and the rate of change in SUVmax following NAC（ΔSUVmax）were determined to examine their relationship with postoperative recurrence and clinicopathological factors.
Results: Receiver operating characteristic curves, with recurrence after NAC as the event, were used to determine optimal cut-off SUVmax and ΔSUVmax of 6.8 and 45.7, respectively. Using these cut-off values, the patients were classified into four groups: Group A, SUVmax > 6.8 and ΔSUVmax ≤ 45.7; Group B, SUVmax > 6.8 and ΔSUVmax > 45.7; Group C, SUVmax ≤ 6.8 and ΔSUVmax ≤ 45.7; and Group D, SUVmax ≤ 6.8 and ΔSUVmax > 45.7. Of the four groups, Group D had the longest RFS compared to the other groups.
Conclusion: Combination of SUVmax with ΔSUVmax was useful for evaluating the effects of NAC in patients with esophageal cancer.},
 pages = {54--66},
 title = {Combined utility of maximum standardized uptake value and its change after neoadjuvant chemotherapy in predicting postoperative recurrence in esophageal cancer},
 volume = {73},
 year = {2023}
}