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Innate Immune Reactions Against RNA Viruses in Renal Mesangial Cells
http://hdl.handle.net/10129/4869
http://hdl.handle.net/10129/4869b67db34a-6029-4244-8204-60b0a212b5a9
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_64_S70.pdf (232.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-30 | |||||
タイトル | ||||||
タイトル | Innate Immune Reactions Against RNA Viruses in Renal Mesangial Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TLR3 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | FN-β | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RIG-I | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ISG20 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DEC2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mesangial cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Imaizumi, Tadaatsu
× Imaizumi, Tadaatsu× Aizawa, Tomomi× Tanaka, Hiroshi× Sato, Fuyuki× Xing, Fei× Matsumiya, Tomoh× Yoshida, Hidemi× Satoh, Kei |
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著者(ヨミ) | ||||||
姓名 | イマイズミ, タダアツ | |||||
著者(ヨミ) | ||||||
姓名 | アイザワ, トモミ | |||||
著者(ヨミ) | ||||||
姓名 | タナカ, ヒロシ | |||||
著者(ヨミ) | ||||||
姓名 | サトウ, フユキ | |||||
著者(ヨミ) | ||||||
姓名 | ジン, フェイ | |||||
著者(ヨミ) | ||||||
姓名 | マツミヤ, トモオ | |||||
著者(ヨミ) | ||||||
姓名 | ヨシダ, ヒデミ | |||||
著者(ヨミ) | ||||||
姓名 | サトウ, ケイ | |||||
著者別名 | ||||||
姓名 | 今泉, 忠淳 | |||||
著者別名 | ||||||
姓名 | 相澤, 知美 | |||||
著者別名 | ||||||
姓名 | 田中, 完 | |||||
著者別名 | ||||||
姓名 | 松宮, 朋穂 | |||||
著者別名 | ||||||
姓名 | 吉田, 秀見 | |||||
著者別名 | ||||||
姓名 | 佐藤, 敬 | |||||
著者所属 | ||||||
Department of Vascular Biology, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of Pediatrics, Hirosaki University Graduate School of Medicine | ||||||
著者所属 | ||||||
Department of School Health Science, Faculty of Education, Hirosaki University | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Viral infection is important in renal pathology both as a trigger of chronic inflammatory diseases and as a complication associated with organ transplantation. Glomerular mesangial cells produce a variety of functional molecules potentially involved in immune reactions, and we investigated anti-viral responses in normal human mesangial cells. Human mesangial cells were treated with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA that mimics viral RNA. Treatment of cells with poly IC induced interferon-β (IFN-β), retinoic acid-inducible gene-I( RIG-I), CC chemokine ligand 5( CCL5), differentiated embryo-chondrocyte 2( DEC2) and IFN-stimulated gene 20 (ISG20). Knockdown of toll-like receptor 3 (TLR3), by RNA interference (RNAi), abolished the poly IC-induced expression of these molecules. RNAi against IFN-β inhibited the induction of RIG-I, CCL5 and ISG20, but not of DEC2. Knockdown of RIG-I resulted in the reduced expression of CCL5. RNAi against DEC2 enhanced the poly IC-induced expression of IFN-β, RIG-I and CCL5. Transfection of cells with a poly IC/cationic lipid complex induced IFN-β, RIG-I and ISG20. Knockdown of RIG-I decreased the expression of IFN-β and ISG20 induced by transfection with poly IC/cationic lipid. TLR3 and RIG-I may function as recognition receptors against double-stranded RNA, which induce IFN-β and its downstream IFN-inducible genes. In the signaling elicited by poly IC, the IFN-inducible genes include RIG-I and effector molecules as CCL5 with leukocyte chemotactic activity and ISG20 with exonuclease activity on single-stranded RNA. The poly IC-induced expression of DEC2 is independent on IFN-β and it may control the signaling elicited by double-stranded RNA. The poly IC-inducible molecules may mediate anti-viral innate responses in renal mesangial cells. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 64(Suppl.), 2013, p.S70-73 | |||||
書誌情報 |
弘前医学 巻 64, 号 Supplement, p. S70-S73, 発行日 2013-04-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |