WEKO3
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Antibody-mediated rejection (AMR) after ABO-incompatible kidney transplantation (ABO-I KTx) is a major barrier to the success of transplantation. The advent of immunosuppressive therapy has markedly improved graft survival in ABO-I KTx. However, compare with a normal KTx, clinical conditions during ABO-IKTx are difficult to control due to over-immunosuppression. To reduce the immunosuppression we try to develop the blood group antigen-neutralizing therapy.\nMethods. We screened an ABO blood group antigen targeting peptide (BATP) by peptide library displayed T7 phage screening. After screening, a hemagglutination( HA) inhibition assay and ELISA assay was used to analyze the blood group antigen blocking effect of the BATP. We also tested the inhibitory effect of anti-blood group Ab binding in normal human kidney tissues blocked with BATP.\nResults. We identified six peptide sequences. 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Blood Group Antigen Targeting Peptide Suppresses Thrombotic Microangiopathy in Renal Glomerular Capillaries after ABO-Incompatible Blood Reperfusion
http://hdl.handle.net/10129/4878
http://hdl.handle.net/10129/48783e86c0f9-e119-4bfb-a6b8-adf0dab6ae24
名前 / ファイル | ライセンス | アクション |
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HirosakiMedJ_64_S121.pdf (309.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-30 | |||||
タイトル | ||||||
タイトル | Blood Group Antigen Targeting Peptide Suppresses Thrombotic Microangiopathy in Renal Glomerular Capillaries after ABO-Incompatible Blood Reperfusion | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Blood group antigen targeting peptide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BATP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ABO-incompatible kidney transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ABO-I KTx | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yoneyama, Tohru
× Yoneyama, Tohru× Hatakeyama, Shingo× Yamamoto, Hayato× Imanishi, Kengo× Okamoto, Teppei× Tokui, Noriko× Sugiyama, Naoki× Suzuki, Yuichiro× Kudo, Shigemasa× Hashimoto, Yasuhiro× Koie, Takuya× Kamimura, Noritaka× Fukuda, Michiko N.× Ohyama, Chikara |
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著者(ヨミ) | ||||||
姓名 | ヨネヤマ, トオル | |||||
著者(ヨミ) | ||||||
姓名 | ハタケヤマ, シンゴ | |||||
著者(ヨミ) | ||||||
姓名 | ヤマモト, ハヤト | |||||
著者(ヨミ) | ||||||
姓名 | イマニシ, ケンゴ | |||||
著者(ヨミ) | ||||||
姓名 | オカモト, テッペイ | |||||
著者(ヨミ) | ||||||
姓名 | トクイ, ノリコ | |||||
著者(ヨミ) | ||||||
姓名 | スギヤマ, ナオキ | |||||
著者(ヨミ) | ||||||
姓名 | スズキ, ユウイチロウ | |||||
著者(ヨミ) | ||||||
姓名 | クドウ, シゲマサ | |||||
著者(ヨミ) | ||||||
姓名 | ヨネヤマ, タカヒロ | |||||
著者(ヨミ) | ||||||
姓名 | ハシモト, ヤスヒロ | |||||
著者(ヨミ) | ||||||
姓名 | コイエ, タクヤ | |||||
著者(ヨミ) | ||||||
姓名 | カミムラ, ノリタカ | |||||
著者(ヨミ) | ||||||
姓名 | フクダ, ミチコ | |||||
著者(ヨミ) | ||||||
姓名 | オオヤマ, チカラ | |||||
著者別名 | ||||||
姓名 | 米山, 徹 | |||||
著者別名 | ||||||
姓名 | 畠山, 真吾 | |||||
著者別名 | ||||||
姓名 | 山本, 勇人 | |||||
著者別名 | ||||||
姓名 | 今西, 賢悟 | |||||
著者別名 | ||||||
姓名 | 岡本, 哲平 | |||||
著者別名 | ||||||
姓名 | 得居, 範子 | |||||
著者別名 | ||||||
姓名 | 杉山, 尚樹 | |||||
著者別名 | ||||||
姓名 | 鈴木, 裕一朗 | |||||
著者別名 | ||||||
姓名 | 工藤, 茂将 | |||||
著者別名 | ||||||
姓名 | 米山, 高弘 | |||||
著者別名 | ||||||
姓名 | 橋本, 安弘 | |||||
著者別名 | ||||||
姓名 | 古家, 琢也 | |||||
著者別名 | ||||||
姓名 | 神村, 典孝 | |||||
著者別名 | ||||||
姓名 | 大山, 力 | |||||
著者所属 | ||||||
Department of Advanced Transplantation & Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki | ||||||
著者所属 | ||||||
Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki | ||||||
著者所属 | ||||||
Oyokyo Kidney Research Institute, Hirosaki | ||||||
著者所属 | ||||||
Glycobiology Unit, Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute | ||||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Antibody-mediated rejection (AMR) after ABO-incompatible kidney transplantation (ABO-I KTx) is a major barrier to the success of transplantation. The advent of immunosuppressive therapy has markedly improved graft survival in ABO-I KTx. However, compare with a normal KTx, clinical conditions during ABO-IKTx are difficult to control due to over-immunosuppression. To reduce the immunosuppression we try to develop the blood group antigen-neutralizing therapy. Methods. We screened an ABO blood group antigen targeting peptide (BATP) by peptide library displayed T7 phage screening. After screening, a hemagglutination( HA) inhibition assay and ELISA assay was used to analyze the blood group antigen blocking effect of the BATP. We also tested the inhibitory effect of anti-blood group Ab binding in normal human kidney tissues blocked with BATP. Results. We identified six peptide sequences. BATP efficiently suppresses hemagglutination of red blood cells caused by anti-ABO blood group antibodies and binding of these antibodies to ABO histo-blood group antigens on kidney tissue. Conclusions. These data indicating that blood group A/B-antigen on RBCs and on kidney tissues may neutralize by BATP. This approach may enable the development of novel blood group antigen neutralizing therapy to overcome the challenges of ABO-I KTx. |
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引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 弘前医学. 64(Suppl.), 2013, p.S121-S128 | |||||
書誌情報 |
弘前医学 巻 64, 号 Supplement, p. S121-S128, 発行日 2013-04-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0439-1721 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00211444 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
日本十進分類法 | ||||||
主題Scheme | NDC | |||||
主題 | 490 | |||||
NIIサブジェクト | ||||||
主題Scheme | Other | |||||
主題 | 医学 | |||||
出版者 | ||||||
出版者 | 弘前大学大学院医学研究科・弘前医学会 | |||||
資源タイプ | ||||||
値 | Article |